Predictors of Myasthenia Gravis Outcome Following Thoracoscopic Thymectomy: Multicenter Comparative Study Between Thymomatous and Non-Thymomatous Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Proportion of patients achieving complete stable remission
研究概览
简要总结
This study aimed to assess and compare predictors of outcome in patients with thymomatous and non-thymomatous MG undergoing Thoracoscopic thymectomy.
详细描述
Myasthenia Gravis (MG) is a chronic autoimmune neuromuscular disorder characterized by fluctuating muscle weakness resulting from antibodies that target acetylcholine receptors or associated proteins at the neuromuscular junction.
Thoracoscopic thymectomy becomes more prominent than traditional transsternal thymectomy due to fewer perioperative complications with shorter hospital stays and more favorable long-term outcomes.
Prognostic outcomes following thoracoscopic thymectomy can vary significantly between non-thymomatous and thymomatous MG, necessitating a thorough investigation of these differences.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Both sexes.
- •Confirmed diagnosis of Myasthenia Gravis (MG).
- •Underwent Thoracoscopic thymectomy.
- •Availability of complete preoperative and postoperative records, including imaging and histopathology.
- •Minimum follow-up of 9 months post-surgery.
排除标准
- •Patients who underwent thymectomy for indications other than MG.
- •Incomplete medical records or loss to follow-up before outcome assessment.
- •Patients with concomitant neuromuscular disorders other than MG
研究组 & 干预措施
Thymomatous Myasthenia Gravis group
Thymomatous myasthenia gravis (patients with histologically confirmed thymoma).
干预措施: Data collection (Other)
Non-thymomatous Myasthenia Gravis group
Non-thymomatous myasthenia gravis (patients with thymic hyperplasia or normal/ involuted thymus).
干预措施: Data collection (Other)
结局指标
主要结局
Proportion of patients achieving complete stable remission
时间窗: 12 months post-procedure
Proportion of patients achieving complete stable remission was recorded.
次要结局
- Proportion of patients achieving pharmacologic remission(12 months post-procedure)
研究者
Mostafa Mohamed Elawady
Lecturer of Neuropsychiatry, Tanta University, Tanta, Egypt.
Tanta University