Dexamethasone for PENG Block in Total Hip Arthroplasty

Phase 4

Completed

• Conditions: Hip Osteoarthritis; Hip Arthropathy; Hip Pain Chronic
• Interventions: Drug: Ropivacaine 0.2% Injectable Solution; Drug: Ropivacaine 0.2% Injectable Solution + 4mg Dexamethasone

• Registration Number: NCT06470139
• Lead Sponsor: Poznan University of Medical Sciences

Brief Summary

Effect of adding Dexamethasone to Periarticular Nerve Group Block in Patients undergoing Total Hip Arthroplasty

Detailed Description

Hip arthroplasty is one of the most common orthopaedic procedures, especially in elderly patients, due to the deformation of joints. Patients may complain of severe pain due to surgical trauma and prostheses. Regional anaesthesia methods may be performed to reduce the inflammatory response, opioid consumption, and opioid-related side effects.

Study Timeline

• Study First Submitted: 2024-06-17
• Study First Submitted QC: 2024-06-17
• Study First Posted: 2024-06-24
• Study Start: 2024-08-13
• Primary Completion: 2025-01-15
• Study Completion: 2025-02-10
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-20
• Last Update Posted: 2025-03-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• patients scheduled for total hip arthroplasty
• patients aged >65 and <100 years
• patients able to provide informed consent
• patients able to reliably report symptoms to the research team

Exclusion Criteria

• inability to provide first-party consent due to cognitive impairment or a language barrier

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Ropivacaine	Ropivacaine 0.2% Injectable Solution	Ultrasound-guided PENG block - 20ml 0,2% ropivacaine + 2ml 0.9% NaCl
Ropivacaine+Dexamethasone	Ropivacaine 0.2% Injectable Solution + 4mg Dexamethasone	Ultrasound-guided PENG block - 20ml 0,2% ropivacaine + 4mg Dexamethasone

Primary Outcome Measures

Name	Time	Method
Time to first rescue opioid analgesia	48 hours after surgery	Time after surgery when the patient needs opiate for the first time

Secondary Outcome Measures

Name	Time	Method
Quadriceps muscle strength assessed using medical research council scale [range 0:5]	48 hours after surgery	Quadriceps muscle strength (knee extension and hip adduction) will be evaluated according to the medical research council muscle strength rating
Nerve damage	48 hours after surgery	Nerve damage assesent will be performed using scale: N0- no nerve damage; N1- minor - sensory paresthesia; N2- majorcomplete sensory anesthesia; N3- Complete- complete motor defect with or without paraesthesia; N4-CRPS- Complex Regional Pain Syndrome
glucose	48 hours after surgery	blood glucose levels
Numerical Rating Scale [range 0:10]	48 hours after surgery	Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt)
Total Opioid Consumption	48 hours after surgery	Total opiate consumption after surgery

Trial Locations

Locations (1)

Poznan University of Medical Sciences; 🇵🇱 Poznan, Poznań, Poland