Isolated central nervous system disease in Familial Hemophagocytic Lymphohistiocytosis (FHL) – a case series

• Conditions: D76.1; Haemophagocytic lymphohistiocytosis

• Registration Number: DRKS00013196
• Lead Sponsor: niversitätsklinikum Freiburg Centrum für Chronische Immundefizienz (CCI) im Zentrum für Translationale Zellforschung

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-09-15
• Study Start: 2019-12-09
• Results First Posted: 2020-08-15
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 38

Inclusion Criteria

1. initial clinical presentation with neurological symptoms;
2. absence of cytopenia and splenomegaly at initial presentation;
3. occurrence of systemic HLH features no earlier than 3 months after neurological presentation;
4. genetic diagnosis of familial Hemophagocytic Lymphohistiocytosis

Exclusion Criteria

no

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
survival

Secondary Outcome Measures

Name	Time	Method
degree of neurological impairment