The Effect of Body Mass Index, Intra-abdominal Pressure, Abdominal Girth and Waist Circumference on Sensory Block Level After Single-shot Spinal Anesthesia for Cesarean Section
试验速览
- 阶段
- 4 期
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- motor block
研究概览
简要总结
Although the exact mechanism remains unknown, the association of pregnancy and decreased local anesthetic requirement is clear. demonstrated that more local anesthetic is required for cesarean section under combined spinal-epidural anesthesia in preterm compared with term patients.
详细描述
However, in pregnant patients, venous engorgement is prominent in the supine but not the lateral position, which suggests direct compression of the inferior vena cava by the gravid uterus. Second, an increase in intraabdominal pressure may affect the retroperitoneal area and may cause inward movement of soft tissue in the intervertebral foramina. Recent magnetic resonance imaging studies in pregnant patients, although without intraabdominal pressure measurements, suggested the latter because they showed limited contact of engorged veins along the dural sac which may therefore not be responsible for compression of the dura.
If elevated intraabdominal pressure contributes to high anesthetic spread during pregnancy, one would expect a relationship between intraabdominal pressure and maximum sensory block level.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •adult female partner
- •aged 18 to 40 years.
- •scheduled for elective cesarean section.
排除标准
- •Patients with coagulopathy or under anti-coagulation therapy.
- •Gastrointestinal disease,
- •motion sickness.
- •diabetes mellitus.
- •Patients with preeclampsia,
研究组 & 干预措施
intrathecal bupivacaine
intrathecal bupivacaine hydrochloride 0.5%,12.5mg
干预措施: Bupivacaine Hydrochloride (Drug)
结局指标
主要结局
motor block
时间窗: from allocation until 24 hours post-operative
effect of different parameters in motor level
sensory level
时间窗: from allocation until 24 hours post-operative
effect of different parameters in sensory level
次要结局
- hypotension(from allocation until 24 hours post-operative)
- vasopressor consumption(from allocation until 24 hours post-operative)
研究者
Ghada Mohammed AboelFadl
Principal Investigator
Assiut University
