The Effect of Some Parturients' Characteristics on Sensory Block Level After Spinal Anesthesia

Phase 4

• Conditions: Anesthesia, Obstetrical
• Interventions: Drug: Bupivacaine Hydrochloride

• Registration Number: NCT03164096
• Lead Sponsor: Assiut University

Brief Summary

Although the exact mechanism remains unknown, the association of pregnancy and decreased local anesthetic requirement is clear. demonstrated that more local anesthetic is required for cesarean section under combined spinal-epidural anesthesia in preterm compared with term patients.

Detailed Description

However, in pregnant patients, venous engorgement is prominent in the supine but not the lateral position, which suggests direct compression of the inferior vena cava by the gravid uterus. Second, an increase in intraabdominal pressure may affect the retroperitoneal area and may cause inward movement of soft tissue in the intervertebral foramina. Recent magnetic resonance imaging studies in pregnant patients, although without intraabdominal pressure measurements, suggested the latter because they showed limited contact of engorged veins along the dural sac which may therefore not be responsible for compression of the dura.

If elevated intraabdominal pressure contributes to high anesthetic spread during pregnancy, one would expect a relationship between intraabdominal pressure and maximum sensory block level.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2017-05-20
• Study First Submitted QC: 2017-05-22
• Study First Posted: 2017-05-23
• Study Start: 2017-06-01
• Status Verified: 2018-01
• Last Update Submitted: 2018-03-28
• Last Update Posted: 2018-03-29
• Primary Completion: 2018-12-01
• Study Completion: 2018-12-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• adult female partner
• aged 18 to 40 years.
• scheduled for elective cesarean section.

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Exclusion Criteria

• Patients with coagulopathy or under anti-coagulation therapy.
• Gastrointestinal disease,
• motion sickness.
• diabetes mellitus.
• Patients with preeclampsia,

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
intrathecal bupivacaine	Bupivacaine Hydrochloride	intrathecal bupivacaine hydrochloride 0.5%,12.5mg

Primary Outcome Measures

Name	Time	Method
motor block	from allocation until 24 hours post-operative	effect of different parameters in motor level
sensory level	from allocation until 24 hours post-operative	effect of different parameters in sensory level

Secondary Outcome Measures

Name	Time	Method
hypotension	from allocation until 24 hours post-operative	incidence of hypotension after spinal anesthesia
vasopressor consumption	from allocation until 24 hours post-operative	total dose of ephedrine consumed by the patients

Trial Locations

Locations (1)

Assiut governorate; 🇪🇬 Assiut, Egypt