The Circadian Rhythm of Potassium and Cystatin C

Completed

• Conditions: Sudden Cardiac Death; Cardiac Arrhythmias
• Interventions: Procedure: Blood withdrawal

• Registration Number: NCT01318746
• Lead Sponsor: University of Erlangen-Nürnberg Medical School

Brief Summary

The potassium value is important to prevent cardiac arrhythmias and sudden cardiac death. In patients with renal failure, the potassium value is not stable and tends to raise. Until now there are no data available if the potassium value has a circadian rhythm and if there are individual changes from day to day.

Detailed Description

Potassium and cystatin c is measured every 2 hours during 24 hours, twice. There are two groups of patients: Patients with eGFR \< 60 ml/min and patients with eGFR \> 60 ml/min

Study Timeline

• Study First Submitted: 2011-03-17
• Study First Submitted QC: 2011-03-17
• Study First Posted: 2011-03-18
• Study Start: 2011-04
• Primary Completion: 2013-04
• Study Completion: 2013-04
• Status Verified: 2018-01
• Last Update Submitted: 2018-01-11
• Last Update Posted: 2018-01-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• at least 18 years old
• normal renal function and impaired renal function (GFR < 60 ml/min) respectively

Exclusion Criteria

• pregnancy
• anaemia (Hb<10 mg/dl)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy group	Blood withdrawal	15 persons with normal renal function
Renal failure	Blood withdrawal	15 persons with renal failure (GFR \< 60 ml/min)

Primary Outcome Measures

Name	Time	Method
Potassium rhythm	twice in 24 hours	15 persons with normal renal function are hospitalized for 24 hours. Blood samples are taken every 2 hours in order to investigate the potassium value.; It is repeated with 5 persons after 2 days, with 5 persons after 4 and with 5 persons after 6 days.

Secondary Outcome Measures

Name	Time	Method
Potassium value in renal failure	twice in 24 hours	15 persons with renal failure (GFR \< 60 ml/min) are hospitalized for 24 hours. Blood samples are taken every 2 hours in order to investigate the potassium value It is repeated with 5 persons after 2 days, with 5 persons after 4 and with 5 persons after 6 days.

Trial Locations

Locations (1)

Clinical Research Unit, Department of Nephrology and Hypertension, University of Erlangen-Nürnberg; 🇩🇪 Erlangen, Germany