Prognostic Markers of Acute Heart Failure With Chronic Kidney Disease

Recruiting

• Conditions: Chronic Kidney Diseases; Biomarker; Acute Heart Failure

• Registration Number: NCT06006819
• Lead Sponsor: Cheng-Hsin General Hospital

Brief Summary

Acute heart failure (AHF) is defined as new or worsening of symptoms and signs of heart failure and is the most frequent cause of unplanned hospital admission in elderly patients. N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is one of the most developed prognostic markers for AHR patients and. NT-pro-BNP has limitations in terms of diagnostic or predictive accuracy in patients with chronic kidney disease (CKD). Plasma proteomics have the potential to examine underlying pathophysiological and prognostic roles, so we compared the plasma proteomic signature to predict outcomes of patients with or without CKD hospitalized for AHF.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-01
• Study First Submitted: 2023-08-17
• Study First Submitted QC: 2023-08-17
• Study First Posted: 2023-08-23
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-21
• Last Update Posted: 2024-08-23
• Primary Completion: 2025-12-23
• Study Completion: 2025-12-23

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 155

Inclusion Criteria

• hospitalized for acute heart failure

Exclusion Criteria

• initial serum NT-proBNP level <300ng/ml, pregnancy, amputated, and end-stage renal disease under regular dialysis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
major adverse cardiovascular events	1 year	mortality, acute myocardial infarction, acute stroke, and heart failure hospitalization

Secondary Outcome Measures

Name	Time	Method
major adverse kidney events	1 year	mortality, new end-stage renal disease, and 30% decline in estimated GFR

Trial Locations

Locations (1)

Cheng Hsin General Hospital; 🇨🇳 Taipei, Baitou District, Taiwan