A Registry Study of Biomarkers in Progression of Acute Heart Failure(BIOMS-POAHF)

Recruiting

• Conditions: Cardiovascular Diseases

• Registration Number: NCT04108182
• Lead Sponsor: Beijing Institute of Heart, Lung and Blood Vessel Diseases

Brief Summary

The registry study aims to discover the prognostic value of bio-markers in acute heart failure

Detailed Description

Not available

Study Timeline

• Study Start: 2015-12
• Status Verified: 2019-09
• Study First Submitted: 2019-09-26
• Study First Submitted QC: 2019-09-26
• Last Update Submitted: 2019-09-26
• Study First Posted: 2019-09-30
• Last Update Posted: 2019-09-30
• Primary Completion: 2025-08
• Study Completion: 2025-10

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 850

Inclusion Criteria

• 1. Patients aged greater than or equal to 18 years with acute exacerbation of chronic heart failure or new heart failure
• 2. With typical symptoms of acute heart failure as follows: Dyspnea, ankle swelling and fatigue (Limited activity endurance), increased jugular pressure, rales and peripheral edema ;
• 3. Plasma concentrations of BNP: BNP>100pg/ML
• 4. Echocardiography: Related structural heart disease (left ventricular hypertrophy and/or left atrial enlargement) and/or diastolic dysfunction

Exclusion Criteria

• 1. Previous history of cancer or renal replacement therapy
• 2.Surgery was performed within a month
• 3.Accompanied by cardiogenic shock, sepsis, pneumonia
• 4.Eligible patients without informed consent form

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of death ( all cause) or readmission for heart failure	a median follow-up of 8.8 months	Number of Death or heart failure related hospitalization within a median follow-up of 8.8 months of discharge

Secondary Outcome Measures

Name	Time	Method
Number of death ( all cause) or readmission for heart failure and cardiovascular mortality	a median follow-up of 8.8 months	Number of Death or heart failure related hospitalization and cardiovascular mortality within a median follow-up of 8.8 months of discharge

Trial Locations

Locations (1)

Beijing Anzhen Hospital; 🇨🇳 Beijing, China