Determinants on Rocuronium Dose for Deep Block in Bariatric Surgery

• Conditions: Bariatric Surgery
• Interventions: Drug: deep neuromuscular blockade in bariatric surgery

• Registration Number: NCT04709406
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

Find out the deciding factor(total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) of neuromuscular blocker dose for deep neuromuscular blockade in bariatric surgery.

Detailed Description

Before the surgery, total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index were measured by height and weight and skeletal muscle mass and body fat were measured by Bioelectrical impedance analysis (InbodyH20B). Find the highest correlation between the 8 factors (total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) and the amount of rocuronium administered to deep neuromuscular blockade in bariatric surgery.

Study Timeline

• Status Verified: 2021-01
• Study Start: 2021-01
• Study First Submitted: 2021-01-12
• Study First Submitted QC: 2021-01-12
• Last Update Submitted: 2021-01-12
• Study First Posted: 2021-01-14
• Last Update Posted: 2021-01-14
• Primary Completion: 2021-10
• Study Completion: 2021-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Patients aged 20-80 and American Society of Anesthesiology Physical Grade (ASA) I-II, who undergo bariatric surgery

Exclusion Criteria

• kidney disease (GFR<60)
• allergy to study drugs
• decline participation
• side effect of propofol and remifentanil
• when anesthesia does not maintain the level of alertness (BIS) below 60 even when the anesthetic dose is increased, or when hemodynamic instability such as bradycardia and hypotension appears

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
obese patients	deep neuromuscular blockade in bariatric surgery	obese patients underwent bariatric surgery

Primary Outcome Measures

Name	Time	Method
the highest correlation coefficient	preoperative 1 days to postoperative 1 days	the relationship of rocuronium for deep neuromuscular blockade in bariatric surgery and 8 factors (corrected body weight, ideal body weight, lean body weight, fat-free mass, body mass index, skeletal muscle mass, body fat)

Secondary Outcome Measures

Name	Time	Method
Recovery time	preoperative 1 days to postoperative 1 days	time from sugammadex injection to TOF ratio \> 0.9
onset time of rocuronium	preoperative 1 days to postoperative 1 days	time from injection of rocuronium 0.6 mg/kg(TBW) to TOF ratio is less than 0.05
time to deep neuromuscular blockade	preoperative 1 days to postoperative 1 days	time from injection of rocuronium 0.6 mg/kg(TBW) to PTC 1