Dose for Deep Neuromuscular Blockade Deciding Factor of Neuromuscular Blocker Dose for Deep Neuromuscular Blockade

• Conditions: Laparoscopic Surgery
• Interventions: Drug: deep neuromuscular blockade

• Registration Number: NCT04688268
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

Find out the deciding factor(total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) of neuromuscular blocker dose for deep neuromuscular blockade.

Detailed Description

Before the surgery, total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index were measured by height and weight and skeletal muscle mass and body fat were measured by Bioelectrical impedance analysis (InbodyH20N). Find the highest correlation between the 8 factors (total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) and the amount of rocuronium administered to deep neuromuscular blockade.

Study Timeline

• Status Verified: 2020-12
• Study First Submitted: 2020-12-23
• Study First Submitted QC: 2020-12-23
• Last Update Submitted: 2020-12-28
• Study First Posted: 2020-12-29
• Last Update Posted: 2020-12-30
• Study Start: 2021-01-10
• Primary Completion: 2021-07-30
• Study Completion: 2021-07-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• patients aged 20-80 and American Society of Anesthesiology Physical Grade (ASA) I-II, who undergo laparoscopic surgery for at least 2 hours under general anesthesia

Exclusion Criteria

• kidney disease (GFR<60)
• allergy to study drugs
• decline participation
• side effect of propofol and remifentanil
• when anesthesia does not maintain the level of alertness (BIS) below 60 even when the anesthetic dose is increased, or when hemodynamic instability such as bradycardia and hypotension appears

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
deep neuromuscular blockade	deep neuromuscular blockade	patients who underwent surgery with deep neuromuscular blockade

Primary Outcome Measures

Name	Time	Method
the highest correlation coefficient	preoperative 1 days to postoperative 1 days	the relationship of rocuronium for deep neuromuscular blockade and 8 factors (corrected body weight, ideal body weight, lean body weight, fat-free mass, body mass index, skeletal muscle mass, body fat)

Secondary Outcome Measures

Name	Time	Method
onset time of rocuronium	preoperative 1 days to postoperative 1 days	time from injection of rocuronium 0.6 mg/kg(TBW) to TOF ratio is less than 0.05
Time to deep neuromuscular blockade	preoperative 1 days to postoperative 1 days	time from injection of rocuronium 0.6 mg/kg(TBW) to PTC 1
Recovery time	preoperative 1 days to postoperative 1 days	time from sugammadex injection to TOF ratio \> 0.9