Defining and characterising malnutrition and sarcopenia in patients undergoing oesophageal and gastric cancer surgery: a pilot observational study.

Not Applicable

Completed

• Conditions: Sarcopenia; Oesophageal cancer; Gastric cancer; Malnutrition; Oesophagectomy surgery; Gastrectomy surgery; Cancer - Oesophageal (gullet); Cancer - Stomach; Surgery - Other surgery; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12622001472763
• Lead Sponsor: Alfred Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2022-09-13
• Study Start: 2022-11-22
• Last Update Posted: 28 November 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Adults greater than or equal to 18 years of age.
Diagnosis of an oesophageal, oesophagogastric junction, or gastric carcinoma.
Eligible for oesophagectomy, total gastrectomy or total extended gastrectomy, partial gastrectomy, or distal gastrectomy with curative intent.
Must be a patient of the Alfred Health Upper Gastrointestinal Surgery unit with multimodal treatment options discussed at The Alfred UGIS oncology multidisciplinary meeting.

Exclusion Criteria

•Patients less than 18 years of age
•Resection of the oesophagus or stomach for reasons other than carcinoma resection
•Planned for a palliative surgical procedure
Resection of benign cancers, e.g. gastrointestinal stromal tumours (GIST)
Ineligible to undergo BIS assessment due to BMI greater than or equal to 35kg/m2, patients with clinical signs of oedema, patients with endocrine diseases that influence body composition (e.g. Cushing syndrome), patients who have a pacemaker or an electronic implantable device, or patients treated with growth hormone. NOTE: these patients will only be excluded from the BIS component of the study, their CT images can still be obtained to assess body composition.
Patients who do not wish to have their medical follow-up at The Alfred Hospital and who are not willing to come to the Alfred for research purposes only
Patients who are unable to comply with the requirements of the study due to cognitive impairment

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assessment of skeletal muscle index (SMI, cm2/m2) and skeletal muscle density (muscle quality), as a composite measure, using computed tomography (CT) image body composition analysis. [Baseline (diagnosis), preoperatively (re-staging), 12 months postoperatively. ];Sarcopenia diagnosis as defined by the European Working Group on Sarcopenia in Older People (EWGSOP) consensus, using the CT body composition results for the muscle assessment component.[Baseline (diagnosis), preoperatively (re-staging), 12 months postoperatively. ]