Effect of Acute Treatment With N2O on Inhibitory Pain Mechanisms in Healthy Subject

Not Applicable

• Conditions: Pain
• Interventions: Drug: Air; Drug: N2O

• Registration Number: NCT01616004
• Lead Sponsor: Tel-Aviv Sourasky Medical Center

Brief Summary

The purpose of this study is to determine whether N2O (laughing gas) has an antinociceptive effects in healthy volunteers.

Detailed Description

10 healthy volunteers will come twice to the pain medicine unit, at 1 visit they'll get N2O and in the second visit they'll get air as placebo, they won't know what they're getting. During the visit they'll get heat stimulus using QST and will have to report their pain using eVAS (scale from 0 to 100 when 0 is no pain and 100 is the worst pain imagine).

Study Timeline

• Status Verified: 2012-06
• Study First Submitted: 2012-06-03
• Study First Submitted QC: 2012-06-08
• Study First Posted: 2012-06-11
• Last Update Submitted: 2014-09-21
• Last Update Posted: 2014-09-23
• Study Start: 2014-10
• Primary Completion: 2015-08
• Study Completion: 2016-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• 18-50 years old
• women and men
• healthy

Exclusion Criteria

• smokers
• medication use pregnant woman cardiovascular disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Air	Air	-
N2O	N2O	N20 70% inhalation 5 minutes O2 100 % inhalation for 5 minutes

Primary Outcome Measures

Name	Time	Method
Pain Scores on the Visual Analog Scale	August 2016

Trial Locations

Locations (1)

Tel Aviv Sourasky Medical Center, Pain Medicine Unit; 🇮🇱 Tel Aviv, Israel