Effect of Acute Treatment With N2O on Inhibitory Pain Mechanisms in Healthy Subject
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Pain Scores on the Visual Analog Scale
Study Overview
Brief Summary
The purpose of this study is to determine whether N2O (laughing gas) has an antinociceptive effects in healthy volunteers.
Detailed Description
10 healthy volunteers will come twice to the pain medicine unit, at 1 visit they'll get N2O and in the second visit they'll get air as placebo, they won't know what they're getting. During the visit they'll get heat stimulus using QST and will have to report their pain using eVAS (scale from 0 to 100 when 0 is no pain and 100 is the worst pain imagine).
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •18-50 years old
- •women and men
Exclusion Criteria
- •medication use pregnant woman cardiovascular disease
Arms & Interventions
Air
Intervention: Air (Drug)
N2O
N20 70% inhalation 5 minutes O2 100 % inhalation for 5 minutes
Intervention: N2O (Drug)
Outcomes
Primary Outcomes
Pain Scores on the Visual Analog Scale
Time Frame: August 2016
Secondary Outcomes
No secondary outcomes reported
