Autonomic Function in COPD and Risk for Atrial Fibrillation

Completed

• Conditions: Chronic Obstructive Pulmonary Disease
• Interventions: Other: Measurement of lung function, electrocardiography, echocardiography and autonomic function

• Registration Number: NCT03871933
• Lead Sponsor: Heinrich-Heine University, Duesseldorf

Brief Summary

In the presented study, autonomic function as well as risk for atrial fibrillation will be assessed to characterize the relation between risk of atrial fibrillation and autonomic function.

Detailed Description

Atrial fibrillation (AF) has been suggested as relevant comorbidity in patients with chronic obstructive pulmonary disease (COPD). The evaluation of the total atrial conduction time via tissue Doppler imaging (PA-TDI interval) can be used to identify patients with increased risk of new onset AF. Autonomic function can be assessed by different non invasive clinical investigations.

The investigators hypothesise that PA-TDI interval is increased in acutely exacerbated COPD (AECOPD) compared within stable COPD and that increased PA-TDI is related to impairment of autonomic function. For this purpose, 25 patients with AECOPD and 25 patients with stable COPD were characterized by clinical characteristics, laboratory tests, lung function, electrocardiography, echocardiography and autonomic function.

Study Timeline

• Study Start: 2019-03-01
• Study First Submitted: 2019-03-11
• Study First Submitted QC: 2019-03-11
• Study First Posted: 2019-03-12
• Primary Completion: 2019-08-31
• Study Completion: 2019-08-31
• Status Verified: 2019-11
• Last Update Submitted: 2019-11-07
• Last Update Posted: 2019-11-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• patients with chronic obstructive pulmonary disease, exacerbated or stable between the age of 40-80 years with sinus rhythm who gave informed written consent

Exclusion Criteria

• Inability to give written consent, acute myocardial infarction with ST-segment elevations in last 30 days, severe acute or chronic renal dysfunction, severe heart failure, atrial fibrillation, severe valve disease, severe hypotension, active malignant disease, active rheumatic disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
AECOPD	Measurement of lung function, electrocardiography, echocardiography and autonomic function	acute exacerbation of COPD
stable COPD	Measurement of lung function, electrocardiography, echocardiography and autonomic function	-

Primary Outcome Measures

Name	Time	Method
total atrial conduction time	Baseline	total atrial conduction time via tissue Doppler imaging (PA-TDI interval)

Secondary Outcome Measures

Name	Time	Method
Baroreflex sensitivity	Baseline	For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive.
Cold face test	Baseline	For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive.
Heart rate variability	Baseline	For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive.
Chemoreflex sensitivity	Baseline	For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive.
Deep breathing test	Baseline	For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive.
Ewing test	Baseline	For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive.
Cold pressure test	Baseline	For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive.

Trial Locations

Locations (1)

University Hospital Düsseldorf, Division of Cardiology, Pulmonary Disease and Vascular Medicine; 🇩🇪 Düsseldorf, Germany