Characterization of Autonomic Function in Patients With Chronic Obstructive Pulmonary Disease - Potential Relevance for Increased Risk of Atrial Fibrillation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Obstructive Pulmonary Disease
- Sponsor
- Heinrich-Heine University, Duesseldorf
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- total atrial conduction time
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
In the presented study, autonomic function as well as risk for atrial fibrillation will be assessed to characterize the relation between risk of atrial fibrillation and autonomic function.
Detailed Description
Atrial fibrillation (AF) has been suggested as relevant comorbidity in patients with chronic obstructive pulmonary disease (COPD). The evaluation of the total atrial conduction time via tissue Doppler imaging (PA-TDI interval) can be used to identify patients with increased risk of new onset AF. Autonomic function can be assessed by different non invasive clinical investigations. The investigators hypothesise that PA-TDI interval is increased in acutely exacerbated COPD (AECOPD) compared within stable COPD and that increased PA-TDI is related to impairment of autonomic function. For this purpose, 25 patients with AECOPD and 25 patients with stable COPD were characterized by clinical characteristics, laboratory tests, lung function, electrocardiography, echocardiography and autonomic function.
Investigators
Klinik für Kardiologie, Pneumologie und Angiologie
Principle Investigator
Heinrich-Heine University, Duesseldorf
Eligibility Criteria
Inclusion Criteria
- •patients with chronic obstructive pulmonary disease, exacerbated or stable between the age of 40-80 years with sinus rhythm who gave informed written consent
Exclusion Criteria
- •Inability to give written consent, acute myocardial infarction with ST-segment elevations in last 30 days, severe acute or chronic renal dysfunction, severe heart failure, atrial fibrillation, severe valve disease, severe hypotension, active malignant disease, active rheumatic disease
Outcomes
Primary Outcomes
total atrial conduction time
Time Frame: Baseline
total atrial conduction time via tissue Doppler imaging (PA-TDI interval)
Secondary Outcomes
- Baroreflex sensitivity(Baseline)
- Cold face test(Baseline)
- Heart rate variability(Baseline)
- Chemoreflex sensitivity(Baseline)
- Deep breathing test(Baseline)
- Ewing test(Baseline)
- Cold pressure test(Baseline)