The role of the brain-heart connection (autonomic nervous system) in Atrial Fibrillation; a common heart rhythm disorder

Not Applicable

• Conditions: Atrial Fibrillation; Cardiovascular - Other cardiovascular diseases; Neurological - Studies of the normal brain and nervous system

• Registration Number: ACTRN12619000186156
• Lead Sponsor: Centre for Heart Rhythm Disorders, The University of Adelaide

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-02-08
• Last Update Posted: 15 July 2019

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

Patients with Atrial Fibrillation (any stage of treatment or type). Control patients - healthy patients without any significant disease, patients with risk factors for AF but without disease as well as patients with other conditions which cause a high heart rate (inappropriate sinus tachycardia, postural tachycardia syndrome or supraventricular tachycardia) as well those with these conditions treated with catheter ablation in an area of the heart different to AF will be studied to compare reflex responses.

Exclusion Criteria

•Hemodynamically relevant cardiac valvular disease, symptomatic coronary artery disease, peripheral artery disease
•Known autonomic disorder (including severe peripheral/autonomic neuropathy in diabetic patients).
oDiabetes itself is not an exclusion
•Significant cognitive impairment
•Parkinson’s disease
•History of stroke
•Poor mobility – unable to enter LBNP chamber
•Unable to have anti-arrhythmic drugs (AAD) and antihypertensives withheld for 5-7 days pre-autonomic testing.

Study & Design

• Study Type: Observational
• Study Design: Not specified