Effect of Different Sedation and Analgesia Strategies on Patients With Mechanical Ventilation
Overview
- Phase
- Phase 4
- Intervention
- Fentanyl, propofol
- Conditions
- Respiratory Insufficiency
- Sponsor
- The Affiliated Hospital of Qingdao University
- Enrollment
- 300
- Primary Endpoint
- ventilator-free days at 28 days
- Status
- Not yet recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
Most patients in ICU are treated with a combination of analgesics and sedatives in most cases. Due to the different mechanism of different sedative and analgesic drugs, different antagonistic or synergistic effects may occur when combined with drugs, resulting in different clinical effects, especially significant effects on ventilators for patients with assisted breathing. Therefore, this study hopes to compare the effects of different sedative and analgesic drug combinations on the duration of mechanical ventilation for patients with ventilators, so as to guide the clinical adoption of a more reasonable sedative and analgesic scheme.
Investigators
JinyanXing
Director
The Affiliated Hospital of Qingdao University
Eligibility Criteria
Inclusion Criteria
- •Adults who are treated with sedation and analgesia for invasive mechanical ventilation
Exclusion Criteria
- •they have baseline severe cognitive impairment; were pregnant or breast-feeding; were blind, deaf ; had second-degree or third-degree heart block or bradycardia requiring intervention; had an allergy to the experimental drugs; had an indication for benzodiazepines; were anticipated to have immediate discontinuation of mechanical ventilation; were expected to have neuromuscular blockade for more than 48 hours; were in a moribund state; or had received mechanical ventilation for more than 96 hours before meeting all inclusion criteria.
Arms & Interventions
F-P group
the combination of fentanyl and propofol
Intervention: Fentanyl, propofol
F-D group
the combination of fentanyl and dexmedetomidine
Intervention: fentanyl and dexmedetomindine
B-P group
the combination of butorphanol and propofol
Intervention: Butorphanol and propofol
B-D group
the combination of butorphanol and dexmedetomidine
Intervention: Butorphanol and dexmedetomindine
Outcomes
Primary Outcomes
ventilator-free days at 28 days
Time Frame: at 28 days