Effect of Different Sedation and Analgesia Strategies on Patients With Mechanical Ventilation
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 300
- 主要终点
- ventilator-free days at 28 days
研究概览
简要总结
Most patients in ICU are treated with a combination of analgesics and sedatives in most cases. Due to the different mechanism of different sedative and analgesic drugs, different antagonistic or synergistic effects may occur when combined with drugs, resulting in different clinical effects, especially significant effects on ventilators for patients with assisted breathing. Therefore, this study hopes to compare the effects of different sedative and analgesic drug combinations on the duration of mechanical ventilation for patients with ventilators, so as to guide the clinical adoption of a more reasonable sedative and analgesic scheme.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults who are treated with sedation and analgesia for invasive mechanical ventilation
排除标准
- •they have baseline severe cognitive impairment; were pregnant or breast-feeding; were blind, deaf ; had second-degree or third-degree heart block or bradycardia requiring intervention; had an allergy to the experimental drugs; had an indication for benzodiazepines; were anticipated to have immediate discontinuation of mechanical ventilation; were expected to have neuromuscular blockade for more than 48 hours; were in a moribund state; or had received mechanical ventilation for more than 96 hours before meeting all inclusion criteria.
研究组 & 干预措施
F-P group
the combination of fentanyl and propofol
干预措施: Fentanyl, propofol (Drug)
F-D group
the combination of fentanyl and dexmedetomidine
干预措施: fentanyl and dexmedetomindine (Drug)
B-P group
the combination of butorphanol and propofol
干预措施: Butorphanol and propofol (Drug)
B-D group
the combination of butorphanol and dexmedetomidine
干预措施: Butorphanol and dexmedetomindine (Drug)
结局指标
主要结局
ventilator-free days at 28 days
时间窗: at 28 days
次要结局
未报告次要终点
研究者
JinyanXing
Director
The Affiliated Hospital of Qingdao University