Epidemiology of Pecan Nut Allergy

• Conditions: Allergic Reaction

• Registration Number: NCT05185362
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

IgE-mediated food allergy can manifest with reactions ranging from hives to anaphylactic shock. The diagnosis is based on the confirmation of sensitization to the food allergen by skin tests (prick) and the determination of specific IgE directed against the food source and molecular allergens. The gold standard remains the oral provocation test, which is performed in a hospital environment. Once the diagnosis is made, an elimination diet is still considered as the cornerstone of treatment for most food allergies.

While some allergies, such as cow's milk or egg, tend to resolve spontaneously, others, such as allergy to pecan nuts, show a tendency to be persistent. In addition, pecan allergy is often characterized by potentially serious clinical reactions, compared to other foods, which can even be life threatening. In our clinical practice, the investigators found that patients with allergies to pecan nuts often present with severe hypersensitivity reactions when challenged orally to this food. Beyond this information, there are few studies regarding pecans. The investigators decided to retrospectively evaluate the results of oral food challenge and of the allergy work-up in our patients sensitized and allergic to pecan nuts, to better understand the current epidemiology of such food allergy.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-11-01
• Status Verified: 2021-12
• Study First Submitted: 2021-12-22
• Study First Submitted QC: 2021-12-22
• Last Update Submitted: 2021-12-22
• Primary Completion: 2022-01-01
• Study First Posted: 2022-01-11
• Last Update Posted: 2022-01-11
• Study Completion: 2022-04-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of challenge-proven pecan allergy	day 1	Prevalence of challenge-proven pecan allergy in sensitized patients

Secondary Outcome Measures

Name	Time	Method
cut-off of specific IgE	day 1	cut-off of specific IgE and of results of prick test to predict pecan allergy in sensitized and allergic patients
Epidemiological characteristics of pecan allergic patient	day 1	Epidemiological characteristics of pecan allergic patient(cypress pollen-induced allergic rhinitis or food allergy to peach)

Trial Locations

Locations (1)

Uhmontpellier; 🇫🇷 Montpellier, France