Defining the Neural Dynamics of Concept Retrieval Using Electrocorticography

Not Applicable

Completed

• Conditions: Aphasia
• Interventions: Behavioral: Concepts

• Registration Number: NCT04620928
• Lead Sponsor: Medical College of Wisconsin

Brief Summary

This study will look at the way activity within the brain changes over time while a person is trying to think about certain everyday concepts. To measure brain activity accurately, we will be using electrodes placed on people's brains during awake brain surgery.

Detailed Description

This study will measure the dynamics of cortical activity among early modal cortex and multimodal cortical regions during conceptual retrieval using electrocorticography. Participants will be patients undergoing awake temporal lobe craniotomies. During the surgery patients will have multiple high-density grids placed to simultaneously record activity in multiple areas while the patient is performing language tasks. Activity in each of these regions will be tested for timing differences and informational directionality to determine the temporal dynamics.

Study Timeline

• Study First Submitted: 2020-11-03
• Study First Submitted QC: 2020-11-03
• Study First Posted: 2020-11-09
• Study Start: 2021-08-02
• Status Verified: 2023-01
• Primary Completion: 2023-01-31
• Study Completion: 2023-01-31
• Last Update Submitted: 2023-01-31
• Last Update Posted: 2023-02-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 4

Inclusion Criteria

• Clinically determined to require an awake left temporal resection of a brain lesion with concurrent language testing.
• English as a first language.

Exclusion Criteria

• Significant preoperative neuropsychological deficits in memory or naming.
• Patients with inability to make decisions regarding their participation in this research project.
• Surgeon does not plan to expose the area of interest or determines that recording during the resection will interfere with his surgical plan.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Concept Retrieval	Concepts	Patients will be given behavioral intervention, and their brain activity recorded.

Primary Outcome Measures

Name	Time	Method
Brain activity	Recorded immediately during experiment	Electrocorticographic brain activity measured from brain surface

Trial Locations

Locations (1)

Medical College of Wisconsin; 🇺🇸 Milwaukee, Wisconsin, United States