Study on medication used in children with stop working of heart
Not Applicable
Completed
- Conditions
- Health Condition 1: I95-I99- Other and unspecified disorders of the circulatory system
- Registration Number
- CTRI/2019/01/017200
- Lead Sponsor
- The Director
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
All patients aged One-month (corrected) to 13 years of adult parents, admitted in pediatric intensive care unit, who require cardiopulmonary resuscitation will be included.
Exclusion Criteria
1. Not able to achieve intravenous or intraosseous access during CPR.
2. ROSC achieved by defibrillation without requirement of Epinephrine.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To compare proportion of patients to achieve the return of spontaneous circulation (ROSC) during pediatric cardio-pulmonary resuscitation in combination of Epinephrine and Vasopressin versus Epinephrine and placebo groups.Timepoint: at end of CPR.
- Secondary Outcome Measures
Name Time Method 1.To compare the survival rate at 24-hour, at Pediatric Intensive Care Unit, at hospital and at 90-days of discharge between the two study groups.Timepoint: 90 days;2.To compare the functional status (as per Pediatric Cerebral Performance Category Scale & Pediatric Overall Performance Category Scale) between two study groups at Pediatric Intensive Care Unit, at hospital and at 90-days of dischargeTimepoint: 90 days;3.To compare the organ support therapy requirement(s) in the two study groups (namely mechanical ventilation & duration, vasoactive therapy & duration, renal replacement therapy & duration, and intracranial pressure monitoring & duration).Timepoint: At PICU discharge;4.To compare the length of stay in pediatric intensive care unit and in hospital in the two study groups.Timepoint: At PICU discharge;5.To compare the number of cardiac arrests requiring resuscitation in the two groups.Timepoint: At PICU discharge;6.To compare the adverse effects(s) of the study drugs.Timepoint: At PICU discharge