Comparison of two commonly used vasoactive agents in children with septic shock
- Conditions
- Health Condition 1: I958- Other hypotension
- Registration Number
- CTRI/2019/05/019078
- Lead Sponsor
- All India Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 67
Children aged 2 months to 17 years with early septic shock, defined as children with suspect or confirmed sepsis and unresolved shock/hypoperfusion after the initial 20ml/kg fluid bolus.
1.Children with fulminant myocarditis
2.Children with unrepaired congenital heart disease
3.Post-operative sepsis/septic shock within 72 hours of bypass surgery.
4.Children with Severe Acute Malnutrition
5.Children with chronic kidney disease.
6.Parents not willing to participate in the study
7.Caregiver/Physician unwilling for patient to be enrolled
8.Post-arrest shock and cardiac dysfunction
9.Moribund patients in whom anticipated survival < 24 hrs (since many are in are in recalcitrant downward spiral of overall condition where the impact of one or other vasoactive may be difficult to assess).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fluid volume in ml/kg required in first 6 hours of beginning vasoactive agentsTimepoint: At 6 hours of enrollment
- Secondary Outcome Measures
Name Time Method MoratlityTimepoint: Measured till 28 days from the time of admission. <br/ ><br>Measured at 28 days or earlier if death occurs.;Organ dysfunction scoresTimepoint: At 24, 48 and 72 hours;Proportion of children achieving shock resolutionTimepoint: Measured at 6,12, 24, 48 and 72 hours of resuscitation