1) Pulmonary function in stable chronic heart failure (CHF). 2) COPD prevalence, underdiagnosis and overdiagnosis in stable CHF patients and its independent predictors. 3) Systemic inflammation in COPD and stable CHF: is there a synergistic effect? - Pulmonary function, COPD and systemic inflammation in CHF.

Rijnstate Ziekenhuis0 个研究点目标入组 369 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•·Stable chronic heart failure patients with left ventricular systolic dysfunction (LVEF < 40%) and/or diastolic dysfunction (E/E* > 15 and LVEF > 50%)
•·Outpatients
•·NYHA class I-IV
•·18 years and older
•·Informed consent

•·Patients who do not meet the inclusion criteria
•·Patients who are not able to cooperate or undergo pulmonary function tests
•·Other diseases that can lead to obstructive lung function: asthma, cystic fibrosis
•·Disorders/diseases that can lead to restrictive lung function:
•oPulmonary: lung surgery (lobectomy/pneumectomy), parenchymal neoplasms, interstitial lung disease, sarcoidosis, pneumoconioses, lung abscess, lobar pneumonia, post-infectious scarring, atelectasis, radiation fibrosis
•oPleural: diffuse pleural thickening, mesothelioma, pleural effusion, pneumothorax
•oNeuromuscular diseases: ALS, poliomyelitis, myopathy, bilateral diaphragmatic paralysis, high spinal cord lesions, myasthenia gravis
•oAbdominal: obesity (BMI > 35)
•oPericardial: major pericardial effusion
•oLarge mediastinal processes
•oCollagenvascular diseases
•·Malignancy with bad prognosis (survival < 6 months)
•·Patients with active infection or inflammatory disease such as rheumatoid arthritis
•·Patients who are already participating in another study within the cardiological department

发起方

Rijnstate Ziekenhuis