Perioperative methadone compared to placebo in elderly hip fracture patients – a randomized controlled trial. Phase two of the MetaHip trial

Sygehus Soenderjylland Soenderborg0 个研究点目标入组 130 人开始时间: 2023年7月10日最近更新: 2024年7月22日

适应症

试验速览

暂无简介。

•Patients diagnosed with an acute hip fracture (incurred <24 hours ago) on x-rays in the emergency department. This includes collum femoris fractures, pertrochanteric fractures, and subtrochanteric fractures., Age = 60 years.

•Multiple fractures., Previous allergic reactions or hypersensitivity towards methadone hydrochloride or sodium chloride., Health conditions preventing treatment: •Chronic obstructive pulmonary disease with either past exacerbations or daily symptoms •History of acute asthma attacks •History of drug-induced eczema •Pulmonary hypertension •Raised intracranial pressure or recent head injury •Pheochromocytoma •History of paralytic ileus •QT-interval prolongation on electrocardiogram (ECG) •Myasthenia gravis •Known liver disorder •Hypotension (systolic blood pressure <100 mmHg at admission)., Concurrent administration with MAO inhibitors or within 2 weeks of suspending treatment with these medicinal products., Concurrent administration of benzodiazepines., Impaired cognitive function e.g. dementia. Patients must be able to give informed consent and be able to ask for supplementary analgesics if needed., Current opioid addiction or intravenous addiction., Multi-trauma patient

发起方

Sygehus Soenderjylland Soenderborg