Altered brain processing of rectal sensation in children with functional fecal incontinence. - fMRI and rectal barostat

Academisch Medisch Centrum0 sites10 target enrollmentStarted: TBDLast updated: May 6, 2024

Conditions

Trial Snapshot

No summary available.

•Adolescents between 12-18 years old who suffer from fecal incontinence for at least 2 years and who fulfill the ROME III criteria for functional constipation or functional non-retentive fecal incontinence will be eligible for enrolment.;Functional constipation is defined by at least 2 of the following criteria: 1) spontaneous defecation frequency <3 per week, 2) fecal incontinence episodes *1 per week, 3) retentive posturing, 4) painful or hard bowel movements, 5) passage of large diameter stools and 6) presence of large fecal mass in the rectum. ;Functional non-retentive fecal incontinence (FNRFI) is defined by all of the following criteria: 1) defecation into places inappropriate to the social context at least once per month, 2) no evidence of an inflammatory, anatomic, metabolic, or neoplastic process that explains the subject*s symptoms, 3) no evidence of fecal retention.
•All study subjects and/or the parents should sign informed consent before enrolment.

•Patients with 1) organic causes of constipation, including Hirschsprung*s disease, muscle disorders, prior recto-anal surgery, spina bifida, mental retardation or hypothyroidism, 2) intercurrent illness or active colitis, 3) known allergy to latex or polyethylene, 4) incapable to verbally cooperate or 5) claustrophobia will be excluded from the study.

Sponsor