Small Intestinal Absorption in Patients With Chronic Obstructive Pulmonary Disease Complicated by Cor Pulmonale: A Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 14
- 主要终点
- Absorption fraction of D-xylose
研究概览
简要总结
Aim: To investigate whether patients with pulmonary hypertension have reduced absorption capacity compared to COPD patients without cor pulmonale potentially due to venous obstruction in the portal vein system.
The presence of cor pulmonale was determined by echocardiography. The concentration of D-xylose and zinc were measured in peripheral blood one, two and three hours after ingestion and used as markers of absorption. Furthermore, urine was collected for five hours to determine the amount of excreted D-xylose.
详细描述
Background: Cor pulmonale is a common complication to Chronic Obstructive Pulmonary Disease (COPD), and may result in increased pressure in the inferior caval vein and stasis of the liver. The chronic pulmonary hypertension may lead to stasis in the veins from the small intestine and thereby compromise absorption of nutrients.
Aim: To investigate whether patients with pulmonary hypertension have reduced absorption capacity compared to COPD patients without cor pulmonale.
Methods: Absorption of D-xylose (25 g) and zinc (132 mg), administered as a single dose, was tested in 14 COPD patients, seven with and seven without cor pulmonale. The presence of cor pulmonale was determined by echocardiography. The concentration of D-xylose and zinc were measured in peripheral blood one, two and three hours after ingestion and used as markers of absorption. Furthermore, urine was collected for five hours to determine the amount of excreted D-xylose.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A diagnosis of COPD
- •Clinically stable = Unchanged medication for COPD for at least 6 months
排除标准
- •Unable to understand Danish
- •Other clinically important heart-disease than chronic right heart changes presumably due to lung disease
- •Clinically significant gastro-intestinal or kidney disease
- •Treatment with corticosteroids for at least 6 months.
研究组 & 干预措施
COPD
Patients with COPD without Cor Pulmonale
干预措施: Absorption test with D-xylose and zink (Diagnostic Test)
COPD + Cor Pulmonale
Patients with Cor Pulmonale in addition
干预措施: Absorption test with D-xylose and zink (Diagnostic Test)
结局指标
主要结局
Absorption fraction of D-xylose
时间窗: 3 hours
plasma concentration, mmol/l
次要结局
- Absorption of zinc(3 hours)
- Absorption fraction of D-xylose(5 hours)
研究者
Jens Rikardt Andersen
Associate Professor
University of Copenhagen