Production of Vitamin D Metabolites by UV-radiation From Solar Bed

Not Applicable

Completed

• Conditions: Production of Vitamin D in Skin When Exposed to UV-B by Solar Bed.
• Interventions: Radiation: UV radiation

• Registration Number: NCT01261039
• Lead Sponsor: Hvidovre University Hospital

Brief Summary

Background:

Some patients do not readily absorb vitamin D from intestine. These patients may be helped by ultraviolet rays, which can come from sunlight or solar beds. When the skin is exposed to ultraviolet B rays (UVB) vitamin D is produced. This usually happens when the skin is exposed to sunlight. Vitamin D can also be ingested trough some foods, mainly fatty fish or supplements.

Vitamin D is important for bone, and long-term vitamin D deficiency can lead to osteoporosis. Vitamin D may also be important for the immune system-including autoimmune diseases-and the cardiovascular system.

Purpose:

The main purpose of the study is to learn more about the production of vitamin D3 in the skin, by ultraviolet radiation.

Study Course:

Day 0: Randomization. Subjects are randomized to two groups. Subjects in both groups will be exposed to light in a solar bed for approximately 10 minutes on the first day, but only one of the solar beds wields ultraviolet rays. The other has a filter, which filters out the ultraviolet rays.

Blood samples are drawn on the first day at following times: Before solar bed, after at 15 minutes, 1, 2, 4 and 6 hours.

Day 1,2,3 and 7 after solar bed exposure:

Blood samples are drawn and adverse events are registered.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-04
• Study First Submitted: 2010-12-15
• Study First Submitted QC: 2010-12-15
• Study First Posted: 2010-12-16
• Primary Completion: 2011-02
• Study Completion: 2011-02
• Status Verified: 2012-03
• Last Update Submitted: 2012-03-15
• Last Update Posted: 2012-03-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Healthy adults

Exclusion Criteria

Abnormal ALT or Creatinine Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Solar bed UV-radiation	UV radiation	Solar bed UV-radiation
Solar bed with UV filter	UV radiation	Solar bed with UV filter

Primary Outcome Measures

Name	Time	Method
Vitamin D 25-OHD	8 days

Secondary Outcome Measures

Name	Time	Method
Changes in other calcium metabolic factors	8 days	Vitamin D3, Mg++, PTH, PO4--, Ca++

Trial Locations

Locations (1)

Hvidovre University Hospital; 🇩🇰 Hvidovre, Denmark