Phototherapy in Persons With Multiple Sclerosis

Phase 1

• Conditions: Multiple Sclerosis

• Registration Number: NCT02365259
• Lead Sponsor: University of Illinois at Urbana-Champaign

Brief Summary

The current study examines the effect of phototherapy equipped with Narrow Band UVB lamps on vitamin D production in persons with MS.

Detailed Description

Participants will be exposed to phototherapy according to the 2014 Guidelines issued by the American Academy of Dermatology 3 days per week over an 8-week period.

Study Timeline

• Study Start: 2015-01
• Status Verified: 2015-02
• Study First Submitted: 2015-02-02
• Study First Submitted QC: 2015-02-10
• Last Update Submitted: 2015-02-10
• Study First Posted: 2015-02-18
• Last Update Posted: 2015-02-18
• Primary Completion: 2016-02
• Study Completion: 2016-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

• Female with multiple sclerosis

Exclusion Criteria

• Inability to stand still in a stabilized fashion without risk of falling for up to 6 minutes
• Known medical history of calcium disorder or knowledge of high calcium levels
• Known medical history of hyper-parathyroidism
• Current supplementation with oral vitamin D
• Known allergy to vitamin D
• History of cancer of any type including but not limited to skin cancer
• Obesity defined as BMI > 30
• Known history of fat malabsorption conditions (i.e., steatorrhea)
• Current use of anti-epileptic medication
• Current use of glucocorticoids
• Fitzpatrick skin types I and VI using the Fitzpatrick skin type analysis
• Recent use of tanning facilities

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change from Baseline in Serum Vitamin D at 4 and 8 weeks	0, 4, and 8 weeks	Venous blood will be collected to quantify levels of circulating Vitamin D.

Secondary Outcome Measures

Name	Time	Method
Change from Baseline in Walking Speed at 4 and 8 weeks	0, 4, and 8 weeks	Participants will walking for 25-feet as fast, but safely, as possible on an instrumented gait mat for measuring gait speed.
Change from Baseline in Cognitive Function at 4 and 8 weeks	0, 4, and 8 weeks	Participants will complete neuropsychological assessments of processing speed and learning and memory.
Change from Baseline in Mood State at 4 and 8 weeks	0, 4, and 8 weeks	Participants will complete a 30-item self-report measure of overall mood.

Trial Locations

Locations (1)

Exercise Neuroscience Research Laboratory; 🇺🇸 Urbana, Illinois, United States