High Intensity Interval- vs Moderate Training on Biomarkers of Endothelial and Cardiovascular Health in Adults: Effect of Postprandial Period

Universidad Santo Tomas1 site in 1 country30 target enrollmentJune 2015

ConditionsMetabolic Diseases

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Metabolic Diseases
Sponsor: Universidad Santo Tomas
Enrollment: 30
Locations: 1
Primary Endpoint: Change from Baseline in endothelial function as measured by flow-mediated vasodilation (FMD)
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Several studies have shown relationship between exercise intensity and improvement cardiometabolic health. It has been suggested that high intensity interval training and also moderate training generate positive effects on metabolic risk factors. For these reasons, it is necessary to clarify which type of training, is more effective to improve cardiometabolic health in latinamerican population.

Registry

clinicaltrials.gov

Start Date

June 2015

End Date

October 2016

Last Updated

9 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Universidad Santo Tomas

Responsible Party

Principal Investigator

Robinson Ramírez-Vélez

Principal Professor. Center of Studies in Physical Activity Measurements, School of Medicine and Health Sciences

Universidad Santo Tomas

Eligibility Criteria

Inclusion Criteria

•Written informed consent.
•Interested in improving health and fitness.

Exclusion Criteria

•Systemic infections.
•Weight loss or gain of \>10% of body weight in the past 6 months for any reason.
•Currently taking medication that suppresses or stimulates appetite.
•Uncontrolled hypertension: systolic blood pressure 160 mm Hg or diastolic blood pressure 95 mm Hg on treatment.
•Gastrointestinal disease, including self-reported chronic hepatitis or cirrhosis, any episode of alcoholic hepatitis or alcoholic pancreatitis within past year inflammatory bowel disease requiring treatment in the past year, recent or significant abdominal surgery (e.g., gastrectomy).
•Diagnosed diabetes (type 1 or 2), fasting impaired glucose tolerance (blood glucose 118 mg/dL), or use of any anti-diabetic medications.
•Currently taking antidepressant, steroid, or thyroid medication, unless dosage is stable (no change for 6 months).
•Any active use of illegal or illicit drugs.
•Current exerciser (\>30 min organized exercise per week).
•Indication of unsuitability of current health for exercise protocol (PARQ).

Outcomes

Primary Outcomes

Change from Baseline in endothelial function as measured by flow-mediated vasodilation (FMD)

Time Frame: Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.

FMD will be measured using the guidelines reported by Corretti et al. The diameter of the brachial artery will be assessed using a high-resolution ultrasound device (Siemens SG-60, USA), equipped with a 7.5 MHz linear array transducer

Secondary Outcomes

Change from Baseline in Triglycerides(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
Change from Baseline in muscular fitness(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
Change from Baseline in LDL Cholesterol(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
Change from Baseline in peak uptake of volume of oxygen(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
Change from Baseline in Blood Pressure(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
Change from Baseline in Body Mass(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
Change from Baseline in Flexibility using the sit and reach test(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
Augmentation index (AIx)(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
Change from Baseline in HDL Cholesterol(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
Change from Baseline in Glucose(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
Change from Baseline in Heart rate variability(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
Change from Baseline in Body Mass Index(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
Change from Baseline in Quality & satisfaction with life by SF Community - short-form survey (SF-12™) Colombian version(Baseline and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
Aortic pulse wave velocity (PWVao)(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)