NCT02738385已完成不适用
High Intensity Interval- vs Moderate Training on Biomarkers of Endothelial and Cardiovascular Health in Adults: Effect of Postprandial Period
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Change from Baseline in endothelial function as measured by flow-mediated vasodilation (FMD)
研究概览
简要总结
Several studies have shown relationship between exercise intensity and improvement cardiometabolic health. It has been suggested that high intensity interval training and also moderate training generate positive effects on metabolic risk factors. For these reasons, it is necessary to clarify which type of training, is more effective to improve cardiometabolic health in latinamerican population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Written informed consent.
- •Interested in improving health and fitness.
排除标准
- •Systemic infections.
- •Weight loss or gain of >10% of body weight in the past 6 months for any reason.
- •Currently taking medication that suppresses or stimulates appetite.
- •Uncontrolled hypertension: systolic blood pressure 160 mm Hg or diastolic blood pressure 95 mm Hg on treatment.
- •Gastrointestinal disease, including self-reported chronic hepatitis or cirrhosis, any episode of alcoholic hepatitis or alcoholic pancreatitis within past year inflammatory bowel disease requiring treatment in the past year, recent or significant abdominal surgery (e.g., gastrectomy).
- •Diagnosed diabetes (type 1 or 2), fasting impaired glucose tolerance (blood glucose 118 mg/dL), or use of any anti-diabetic medications.
- •Currently taking antidepressant, steroid, or thyroid medication, unless dosage is stable (no change for 6 months).
- •Any active use of illegal or illicit drugs.
- •Current exerciser (>30 min organized exercise per week).
- •Indication of unsuitability of current health for exercise protocol (PARQ).
- •Any other conditions which, in opinion of the investigators, would adversely affect the conduct of the trial.
结局指标
主要结局
Change from Baseline in endothelial function as measured by flow-mediated vasodilation (FMD)
时间窗: Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.
FMD will be measured using the guidelines reported by Corretti et al. The diameter of the brachial artery will be assessed using a high-resolution ultrasound device (Siemens SG-60, USA), equipped with a 7.5 MHz linear array transducer
次要结局
- Change from Baseline in Triglycerides(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
- Change from Baseline in muscular fitness(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
- Change from Baseline in LDL Cholesterol(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
- Change from Baseline in peak uptake of volume of oxygen(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
- Change from Baseline in Blood Pressure(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
- Change from Baseline in Body Mass(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
- Change from Baseline in Flexibility using the sit and reach test(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
- Augmentation index (AIx)(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
- Change from Baseline in HDL Cholesterol(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
- Change from Baseline in Glucose(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
- Change from Baseline in Heart rate variability(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
- Change from Baseline in Body Mass Index(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
- Change from Baseline in Quality & satisfaction with life by SF Community - short-form survey (SF-12™) Colombian version(Baseline and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
- Aortic pulse wave velocity (PWVao)(Baseline, 2 and 12 weeks immediately after the interventions ends, preceding an 'unhealthy' meal.)
研究者
Robinson Ramírez-Vélez
Principal Professor. Center of Studies in Physical Activity Measurements, School of Medicine and Health Sciences
Universidad Santo Tomas
研究点 (1)
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