High Intensity Interval- vs Resistance or Combined- Training for Improving Cardiometabolic Health in Overweight Adults (Cardiometabolic HIIT-RT Study): Study Protocol for a Factorial Randomised Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Metabolic Diseases
- Sponsor
- Universidad Santo Tomas
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Change from Baseline in endothelial function as measured by flow-mediated vasodilation (FMD)
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Several studies have shown relationship between exercise intensity and improvement cardiometabolic health such as body composition, endothelial function, blood pressure and blood lipids. It has been suggested that high intensity interval training and also strength or resistance training generate positive effects on metabolic risk factors, nevertheless the comparison between both types of training and their combination has not yet provided conclusive evidence. Also, it has been shown that dietary restriction has similar or more positive effects that exercise alone and the effect is greater when it is combined with exercise. For these reasons, it is necessary to clarify which type of training, in combination with a dietary restriction, is more effective to improve cardiometabolic health
Detailed Description
The investigators hypothesized that high intensity interval, resistance training or combined training would result in similar improvements in cardiometabolic health as compared to the usual clinical care in a cohort of sedentary overweight (age 30-50 years old).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Meets at least one criteria for metabolic Syndrome (IDF 2006): Central obesity: waist circumference ≥90cm (men) ≥80cm (women); triglycerides ≥ 150mg/dl; HDL-c \<40mg/dl (men) \<50 (women); Blood pressure ≥130/85mmHg and fasting plasma glucose ≥ 100mg/dL.
- •Written informed consent.
- •Interested in improving health and fitness.
Exclusion Criteria
- •Systemic infections.
- •Weight loss or gain of \>10% of body weight in the past 6 months for any reason.
- •Currently taking medication that suppresses or stimulates appetite.
- •Uncontrolled hypertension: systolic blood pressure 160 mm Hg or diastolic blood pressure 95 mm Hg on treatment.
- •Gastrointestinal disease, including self-reported chronic hepatitis or cirrhosis, any episode of alcoholic hepatitis or alcoholic pancreatitis within past year, inflammatory bowel disease requiring treatment in the past year, recent or significant abdominal surgery (e.g., gastrectomy).
- •Diagnosed diabetes (type 1 or 2), fasting impaired glucose tolerance (blood glucose 118 mg/dL), or use of any anti-diabetic medications.
- •Currently taking antidepressant, steroid, or thyroid medication, unless dosage is stable (no change for 6 months).
- •Any active use of illegal or illicit drugs.
- •Current exerciser (\>30 min organized exercise per week).
- •Indication of unsuitability of current health for exercise protocol (PARQ).
Outcomes
Primary Outcomes
Change from Baseline in endothelial function as measured by flow-mediated vasodilation (FMD)
Time Frame: Baseline and 12 weeks immediately after the interventions ends
FMD will be measured using the guidelines reported by Corretti et al. The diameter of the brachial artery will be assessed using a high-resolution ultrasound device (Siemens SG-60, USA), equipped with a 7.5 MHz linear array transducer.
Secondary Outcomes
- Change from Baseline in muscular fitness(Baseline and 12 weeks immediately after the interventions ends)
- Change from Baseline in peak uptake of volume of oxygen(Baseline and 12 weeks immediately after the interventions ends)
- Change from Baseline in Triglycerides(Baseline and 12 weeks immediately after the interventions ends)
- Change from Baseline in Heart rate variability(Baseline and 12 weeks immediately after the interventions ends)
- Change from Baseline in body Composition as measured by Dual Energy X-ray Absorptiometry(Baseline and 12 weeks immediately after the interventions ends)
- Blood Pressure(Baseline and 12 weeks immediately after the interventions ends)
- Change from Baseline in Quality & satisfaction with life by SF Community - short-form survey (SF-12™) Colombian version(Baseline and 12 weeks immediately after the interventions ends)
- Body Mass Index(Baseline and 12 weeks immediately after the interventions ends)
- Change from Baseline in LDL Cholesterol(Baseline and 12 weeks immediately after the interventions ends)
- Change from Baseline in HDL Cholesterol(Baseline and 12 weeks immediately after the interventions ends)
- Change from Baseline in Hemoglobin A1c(Baseline and 12 weeks immediately after the interventions ends)
- Body Weight(Baseline and 12 weeks immediately after the interventions ends)
- Change from Baseline in Flexibility using the sit and reach test(Baseline and 12 weeks immediately after the interventions ends)
- Change from Baseline in Glucose(Baseline and 12 weeks immediately after the interventions ends)
- 24-hour dietary recall(Baseline and 12 weeks immediately after the interventions ends)
- Aortic pulse wave velocity (PWVao) and augmentation index (AIx)(Baseline and 12 weeks immediately after the interventions ends)