Clinical Trials/NCT00606242

NCT00606242

Completed

Phase 4

A Randomized Double Blind Study of the Dose Response Effects of Fluticasone Propionate on Hypertonic-saline Induced Bronchoconstriction in Asthmatic Subjects

University of California, San Francisco1 site in 1 country44 target enrollmentJanuary 2000

ConditionsAsthma

InterventionsFluticasone

DrugsFluticasone

Overview

Phase: Phase 4
Intervention: Fluticasone
Conditions: Asthma
Sponsor: University of California, San Francisco
Enrollment: 44
Locations: 1
Primary Endpoint: FEV1
Status: Completed
Last Updated: 12 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

This study investigates the effect of a inhaled corticosteroid (fluticasone or "Flovent") on airway narrowing induced by hypertonic saline (salty water). The study hypothesis is that fluticasone will be more effective in preventing saline-induced airway narrowing than methacholine-induced narrowing.

Registry

clinicaltrials.gov

Start Date

January 2000

End Date

December 2007

Last Updated

12 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University of California, San Francisco

Eligibility Criteria

Inclusion Criteria

•Clinical diagnosis of asthma

Exclusion Criteria

•Habitual cigarette smoking

Arms & Interventions

Low dose steroid

Fluticasone, 100 mcg per day

Intervention: Fluticasone

High dose steroid

Fluticasone, 1000 mcg per day

Intervention: Fluticasone

Outcomes

Primary Outcomes

FEV1

Time Frame: Measured every 2 weeks

Secondary Outcomes

PC20 methacholine(Measured every 2 weeks)

Study Sites (1)

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