Dose Response Effects of Inhaled Fluticasone on Airway Effects of Hypertonic-saline in Asthma

Phase 4

Completed

• Conditions: Asthma
• Interventions: Drug: Fluticasone

• Registration Number: NCT00606242
• Lead Sponsor: University of California, San Francisco

Brief Summary

This study investigates the effect of a inhaled corticosteroid (fluticasone or "Flovent") on airway narrowing induced by hypertonic saline (salty water). The study hypothesis is that fluticasone will be more effective in preventing saline-induced airway narrowing than methacholine-induced narrowing.

Detailed Description

Not available

Study Timeline

• Study Start: 2000-01
• Primary Completion: 2002-12
• Study Completion: 2007-12
• Study First Submitted: 2008-01-21
• Study First Submitted QC: 2008-01-21
• Study First Posted: 2008-02-01
• Status Verified: 2014-03
• Last Update Submitted: 2014-03-06
• Last Update Posted: 2014-03-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

• Clinical diagnosis of asthma

Exclusion Criteria

• Habitual cigarette smoking

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Low dose steroid	Fluticasone	Fluticasone, 100 mcg per day
High dose steroid	Fluticasone	Fluticasone, 1000 mcg per day

Primary Outcome Measures

Name	Time	Method
FEV1	Measured every 2 weeks

Secondary Outcome Measures

Name	Time	Method
PC20 methacholine	Measured every 2 weeks

Trial Locations

Locations (1)

University of California, San Francisco; 🇺🇸 San Francisco, California, United States