NL-OMON41799已完成2 期
Grey matter microglial imaging with [18F]DPA-714 in progressive MS patients - [18F]DPA-714 PET in MS
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 23
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- For the MS patient group: diagnosis primary or secondary progressive MS with EDSS scores 4.0 to 7.5
- •- 18 to 60 years
- •- Written informed consent
- •- No immunomodulating or immunosuppressive treatment in previous three months
排除标准
- •- Inability to undergo MRI, e.g. metal objects in or around the body, claustrophobia or inability to lie still in the scanner. For the MS patients: contra-indication for gadolinium administration, e.g. previous allergic reaction to gadolinium.
- •- Homozygote Ala(147)Thr genotype (low-affinity binders)
- •- Significant immune disease other than MS
- •- (History of) other relevant neurological disease
- •- History of malignancy
- •- Known significant cardiac disease
- •- Inadequate renal function: creatinine clearance <60 ml/min
- •- Loss or donation of blood over 500 mL within four months prior to screening.
- •- In male subjects Hb <8.0 g/dL, in female subjects Hb <7.0 g/dL
- •- Pregnant or breast feeding
- •- (History of) alcohol and/or drug abuse
- •- Exposure to previous radiation leading to annual cumulative dose of more than 10 mSV if participating in this protocol
- •- Use of benzodiazepines within 1 week of the PET scan
研究者
相似试验
进行中（未招募）
不适用
Imaging of inflammation in the cortex of the brain in progressive MS patientsProgressive multiple sclerosis, both primary and secondary progressiveMedDRA version: 17.1Level: PTClassification code 10063401Term: Primary progressive multiple sclerosisSystem Organ Class: 10029205 - Nervous system disordersMedDRA version: 17.1Level: PTClassification code 10063400Term: Secondary progressive multiple sclerosisSystem Organ Class: 10029205 - Nervous system disordersMedDRA version: 17.1Level: PTClassification code 10053395Term: Progressive multiple sclerosisSystem Organ Class: 10029205 - Nervous system disordersEUCTR2014-002547-17-NLVU University Medical Center
进行中（未招募）
不适用
Glioma Mesoscopic ImagingC71.9D43.2Brain, unspecifiedDRKS00005580niversitätsklinikum Freiburg37
已完成
不适用
Imaging activated microglia in relapsing remitting multiple sclerosis: a first in human P2X7r PET studymultiple sclerosisNL-OMON47369Vrije Universiteit Medisch Centrum20
已完成
不适用
Astroglia imaging using 11C-deprenyl PET in neurological diseasesneurological diseasesJPRN-UMIN000037684Tokyo Metropolitan Institute of Gerontology20
尚未招募
不适用
Gadolinium enhanced MR imaging of healthy volunteers using 3Tesla MR: evaluation of contrast material leakage into body fluidHealthy individualJPRN-UMIN000008374Department of Radiology, Nagoya University Graduate School of Medicine20