NCT02733146已完成不适用
Histones and Free-plasma DNA in the Days Following the Cardiac Arrest
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Plasma histones
研究概览
简要总结
To evaluate the significance of free-plasma deoxyribonucleic acid (DNA) and plasma histones in cardiac arrest patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Out of hospital cardiac arrest of presumed cardiac cause
- •Return of spontaneous circulation (ROSC)
- •Glasgow Coma Score < 8
- •Age > 18 years and < 80 years
排除标准
- •>60 minutes from the circulatory collapse to ROSC
- •Time interval > 4 hours from cardiac arrest to initiation of targeted temperature management
- •Terminal illness
- •Coagulation disorder
- •Unwitnessed asystolia
- •Cerebral performance category 3-4 before the cardiac arrest
- •Severe persistent cardiogenic shock
- •Pregnancy
- •Persistent cardiogenic shock (systolic blood pressure < 80 despite inotropic treatment)
- •New apoplexy or intracerebral hemorrhage
- •Lack of consent from the relatives
- •Lack of consent from the general practitioner
- •Lack of consent from the patient if he/she wakes up and is relevant
结局指标
主要结局
Plasma histones
时间窗: Approximate 24 hours after cardiac arrest
The level of plasma histones
Free-plasma DNA
时间窗: Approximate 24 hours after cardiac arrest
The level of total free-plasma DNA
次要结局
- Plasma histones(Approximate 48 hours and 72 hours after cardiac arrest)
- Free-plasma DNA(Approximate 48 hours and 72 hours after cardiac arrest)
研究者
研究点 (1)
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