Histones and Free-plasma DNA After Cardiac Arrest

Completed

• Conditions: Heart Arrest; Post Cardiac Arrest Syndrome; Hypothermia
• Interventions: Other: cardiac arrest

• Registration Number: NCT02733146
• Lead Sponsor: University of Aarhus

Brief Summary

To evaluate the significance of free-plasma deoxyribonucleic acid (DNA) and plasma histones in cardiac arrest patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-10
• Study First Submitted: 2016-03-30
• Study First Submitted QC: 2016-04-04
• Study First Posted: 2016-04-11
• Primary Completion: 2016-06
• Study Completion: 2016-09
• Status Verified: 2017-06
• Last Update Submitted: 2017-06-01
• Last Update Posted: 2017-06-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

• Out of hospital cardiac arrest of presumed cardiac cause
• Return of spontaneous circulation (ROSC)
• Glasgow Coma Score < 8
• Age > 18 years and < 80 years

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Exclusion Criteria

• >60 minutes from the circulatory collapse to ROSC
• Time interval > 4 hours from cardiac arrest to initiation of targeted temperature management
• Terminal illness
• Coagulation disorder
• Unwitnessed asystolia
• Cerebral performance category 3-4 before the cardiac arrest
• Severe persistent cardiogenic shock
• Pregnancy
• Persistent cardiogenic shock (systolic blood pressure < 80 despite inotropic treatment)
• New apoplexy or intracerebral hemorrhage
• Lack of consent from the relatives
• Lack of consent from the general practitioner
• Lack of consent from the patient if he/she wakes up and is relevant

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
cardiac arrest patients	cardiac arrest	Patients who has suffered a cardiac arrest

Primary Outcome Measures

Name	Time	Method
Plasma histones	Approximate 24 hours after cardiac arrest	The level of plasma histones
Free-plasma DNA	Approximate 24 hours after cardiac arrest	The level of total free-plasma DNA

Secondary Outcome Measures

Name	Time	Method
Plasma histones	Approximate 48 hours and 72 hours after cardiac arrest	The level of plasma histones
Free-plasma DNA	Approximate 48 hours and 72 hours after cardiac arrest	The level of total free plasma DNA

Trial Locations

Locations (1)

Dept of Anesthesiology and Intensive Care and Dept of Clinical Biochemistry, Aarhus University Hospital; 🇩🇰 Aarhus, Aarhus N, Denmark