Assessment of Dry Eye Disease and Retinal Nerve Fiber Layer Thickness in Chronic Smokers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Non-invasive tear film breakup time
研究概览
简要总结
This study aimed to examine the impact of long-term smoking on dry eye parameters and retinal nerve fiber layer thickness in individuals who are chronic smokers.
详细描述
Dry eye disease (DED) is a multifaceted disorder of the ocular surface characterized by instability of the tear film, which subsequently leads to symptoms such as ocular discomfort, visual disturbances, and potential damage to the surface of the eye.
Cigarette smoking has been recognized as a possible contributing factor to the development of DED, with various reports suggesting that it may alter tear film composition and stability, leading to ocular surface damage.
Chronic smoking can lead to oxidative stress, vascular dysfunction, and inflammation, which may contribute to retinal nerve fiber layer (RNFL) thinning and optic nerve damage.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age from 30 to 60 years.
- •Both sexes.
- •Chronic smokers.
排除标准
- •History of ocular surface diseases affecting tear production or secretion (such as Sjogren's syndrome or Stevens-Johnson disease).
- •Conjunctivitis.
- •Blepharitis.
- •Chronic contact lens use or gross lid abnormalities.
- •Preexisting glaucoma.
- •Retinal diseases.
- •Optic nerve pathology.
- •Ocular trauma.
- •Chemical burns.
- •Recent eye surgery (within three months).
- •Trachoma-related complications
结局指标
主要结局
Non-invasive tear film breakup time
时间窗: During examination (Baseline)
Non-invasive tear film breakup time (NIBUT) was automatically analyzed using artificial intelligence, with results classified as Grade 0 (normal, first rupture time \>10s), Grade 1 (warning, 6- 9s), or Grade 2 (dry eye, ≤5s)
次要结局
- Tear meniscus height(During examination (Baseline))
- Lipid layer thickness(During examination (Baseline))
- Ocular Surface Disease Index (OSDI) score(During examination (Baseline))
- Retinal nerve fiber layer thickness(During examination (Baseline))
- Correlations between dry eye parameters and Ocular Surface Disease Index (OSDI) score(During examination (Baseline))
- Correlations between dry eye parameters and retinal nerve fiber layer (RNFL) thickness in both groups(During examination (Baseline))
研究者
Merna Tharwat Wanees Nakhla
Resident of Ophthalmology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Cairo University