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Clinical Trials/JPRN-UMIN000028641
JPRN-UMIN000028641Completed未知

Role of gastric mucosal barrier dysfunction during gastric carcinogenesis after H.pylori eradication - Mucosal barrier dysfunction during gastric carcinogenesis after H.pylori eradication

Tohoku university0 sites40 target enrollmentStarted: September 22, 2017Last updated:
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Conditions

Trial Snapshot

Phase
未知
Status
Completed
Enrollment
40
Study OverviewEligibility CriteriaInvestigatorsRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

Methods: To evaluate barrier function of background mucosa against the stimulations, we applied biopsy samples from 76 patients on mini-Ussing chamber system and immunohistochemical study. Results: In the UCs, Pg. lipopolysaccharide reduced the impedance of metaplastic and inflamed mucosa with increases in mRNA expression of toll-like receptor 2, tumor necrosis factor, and apoptotic markers.

Study Design

Study Type
Interventional

Eligibility Criteria

Ages
20years-old to 85years-old (—)
Sex
All

Inclusion Criteria

  • Not provided

Exclusion Criteria

  • •1. contraindication for endoscoic biopsy 2. patients who take NSAIDs, steroid, or immunosuppressive medication 3. patients treated by surgecy for upper GI tract 4. patients who take antibiotics in 12 months 5. pregnancy 6. severe general condition or phycological dysorder 7. inappropriate for enrolling this trial

Investigators

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