Role of gastric mucosal barrier dysfunction during gastric carcinogenesis after H.pylori eradicatio
Not Applicable
- Conditions
- gastric cancer after successful eradication
- Registration Number
- JPRN-UMIN000028641
- Lead Sponsor
- Tohoku university
- Brief Summary
Methods: To evaluate barrier function of background mucosa against the stimulations, we applied biopsy samples from 76 patients on mini-Ussing chamber system and immunohistochemical study. Results: In the UCs, Pg. lipopolysaccharide reduced the impedance of metaplastic and inflamed mucosa with increases in mRNA expression of toll-like receptor 2, tumor necrosis factor, and apoptotic markers.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
1. contraindication for endoscoic biopsy 2. patients who take NSAIDs, steroid, or immunosuppressive medication 3. patients treated by surgecy for upper GI tract 4. patients who take antibiotics in 12 months 5. pregnancy 6. severe general condition or phycological dysorder 7. inappropriate for enrolling this trial
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in mucosal barrier dysfunction caused by acetaldehyde or peptideglycan
- Secondary Outcome Measures
Name Time Method