NCT06596070Not yet recruitingNot Applicable
Clinical Study of Intestinal Barrier Dysfunction in Patients After Gastrointestinal Surgery
The Second Affiliated Hospital of Kunming Medical University0 sites180 target enrollmentStarted: October 2024Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 180
- Primary Endpoint
- operating time
Study Overview
Brief Summary
The goal of this observational study is to explore the clinical influences associated with the development of intestinal barrier dysfunction in patients undergoing gastrointestinal surgery. The main question it aims to answer is:What clinical factors increase the probability of developing intestinal barrier dysfunction in patients after gastrointestinal surgery?
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •men or women aged 18-80 years
- •expected feasible abdominal surgical treatment (partial gastrectomy, colorectal resection)
- •no preoperative intestinal barrier dysfunction
- •patients voluntarily participated in this study and signed an informed consent form.
Exclusion Criteria
- •Patients or their families refused to participate in this study
- •chronic inflammatory diseases (e.g. inflammatory bowel disease, chronic hepatitis, chronic pancreatitis, chronic peptic ulcer, etc.)
- •history of antibiotic administration in the last 2 weeks
- •severe cognitive impairment and other inability to cooperate preoperative neoadjuvant radiotherapy
- •combined with severe hepatic, renal, and cardiac insufficiency patients.
Outcomes
Primary Outcomes
operating time
Time Frame: During surgery
Record the patient\'s surgical time
Secondary Outcomes
- nutritional status(Preoperative)
- bowel habit(Preoperative)
- Surgical Procedures(During surgery)
- hemorrhage(During surgery)
- Albumin(Preoperative and postoperative 24 hours)
- Infection indicators(Preoperative and postoperative 24 hours)
- age(Preoperative)
- gender(Preoperative)
- Body Mass Index(Preoperative)
- diabetes(Preoperative)
- enteral nutrition(The average observation time is 2 weeks after surgery.)
- Exhaust and defecation time(The average observation time is one week after surgery)
Investigators
Weiming Li
Investigator
The Second Affiliated Hospital of Kunming Medical University
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