Clinical Study of Intestinal Barrier Dysfunction After Gastrointestinal Surgery

Not yet recruiting

• Conditions: Intestinal Barrier Dysfunction
• Interventions: Other: No intervention was carried out

• Registration Number: NCT06596070
• Lead Sponsor: The Second Affiliated Hospital of Kunming Medical University

Brief Summary

The goal of this observational study is to explore the clinical influences associated with the development of intestinal barrier dysfunction in patients undergoing gastrointestinal surgery. The main question it aims to answer is:What clinical factors increase the probability of developing intestinal barrier dysfunction in patients after gastrointestinal surgery?

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-09
• Study First Submitted: 2024-09-07
• Study First Submitted QC: 2024-09-12
• Last Update Submitted: 2024-09-12
• Study First Posted: 2024-09-19
• Last Update Posted: 2024-09-19
• Study Start: 2024-10
• Primary Completion: 2025-01
• Study Completion: 2025-04

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

• men or women aged 18-80 years
• expected feasible abdominal surgical treatment (partial gastrectomy, colorectal resection)
• no preoperative intestinal barrier dysfunction
• patients voluntarily participated in this study and signed an informed consent form.

Exclusion Criteria

• Patients or their families refused to participate in this study
• chronic inflammatory diseases (e.g. inflammatory bowel disease, chronic hepatitis, chronic pancreatitis, chronic peptic ulcer, etc.)
• history of antibiotic administration in the last 2 weeks
• severe cognitive impairment and other inability to cooperate preoperative neoadjuvant radiotherapy
• combined with severe hepatic, renal, and cardiac insufficiency patients.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Intestinal barrier dysfunction group	No intervention was carried out	-
Non-intestinal barrier dysfunction group	No intervention was carried out	-

Primary Outcome Measures

Name	Time	Method
operating time	During surgery	Record the patient\'s surgical time

Secondary Outcome Measures

Name	Time	Method
nutritional status	Preoperative	Patients were assessed for risk of malnutrition by the Nutritional Risk Screening Scale (NRS-2002). A score of ≥3 indicated that the patient was at risk of malnutrition.
bowel habit	Preoperative	The patient was asked whether there were increased frequency of stool, changes in stool characteristics, constipation and other conditions before surgery
Surgical Procedures	During surgery	Record whether the patient underwent laparoscopic surgery or open surgery
hemorrhage	During surgery	Record the patient\'s intraoperative bleeding volume
Albumin	Preoperative and postoperative 24 hours	Record the patient\'s albumin levels before and 24 hours after surgery
Infection indicators	Preoperative and postoperative 24 hours	Record the values of PCT, IL-6, and CRP of patients before and 24 hours after surgery
age	Preoperative
gender	Preoperative
Body Mass Index	Preoperative
diabetes	Preoperative	Record whether the patient has diabetes
enteral nutrition	The average observation time is 2 weeks after surgery.	Record the start time of enteral nutrition for patients after surgery.
Exhaust and defecation time	The average observation time is one week after surgery	Record the time of the patient\'s first exhaust and first bowel movement after surgery