Combined electromyography-functional MRI in patients with tremor for improvement of targeting in stereotactic surgery
- Conditions
- shakingtremblingtremor10028037
- Registration Number
- NL-OMON30841
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
Previous thalamotomy for the treatment of tremor or inclusion in the waiting list for DBS;Presence of tremor in at least one arm ;Age above 18 years
Exclusion Criteria
MR-incompatible implanted metal bodies, including stereotactic implant for Deep Brain Stimulation.;Other contraindications for MR (Claustrophobia, obesity, etc.);Previous brain surgery other than thalamotomy ;Use of medicines/drugs that could influence the performance during the tasks (such as anti-epileptic drugs, neurodepressants, etc.);Pregnancy or suspected pregnancy;Incapability to give informed consent
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>We will evaluate the predictive value of EMG-fMRI by correlating the overlap of<br /><br>the area defined by EMG-fMRI with the surgical area, and with clinical outcome<br /><br>of surgery. Effectiveness of treatment (thalamotomy or DBS) will be assessed<br /><br>according to the change in the score of specific clinical scales (UPDRS and<br /><br>TRS). </p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>