Pelvic Angiography in Non-Responders to Phosphodiesterase-5 Inhibitors (PANPI)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 主要终点
- Distal aortography with iliofemoral run-off will be performed to evaluate disease in the common and internal iliac arteries.
研究概览
简要总结
The specific aim of this pilot study is to describe the angiographic prevalence and pattern of internal pudendal artery (and associated inflow vessel) atherosclerosis in patients with erectile dysfunction who are non-responsive to PDE-5 inhibitors (i.e., Viagra) who are referred for clinically-indicated cardiac catheterization.
详细描述
The specific aim of this study is to determine if the deep penile arteries can be seen angiographically from the iliac arteries to delineate penile vasculature. Significant obstructive atherosclerotic disease of the deep penile arteries may be present in impotent males. The etiology of erectile dysfunction is multifactorial and may involve vascular disease, endocrine disorders, neurologic disease, prescription medications, psychological issues and/or trauma in any given patient. Vascular disease in patients with erectile dysfunction may be due to trauma, congenital anomalies, or atherosclerosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Male patients
- •at least 50 years
- •erectile dysfunction
- •dissatisfaction with their use of a phosphodiesterase-5 inhibitor
- •coronary artery disease (or at risk for coronary artery disease)
- •undergoing diagnostic cardiac catheterization or patients with peripheral vascular disease undergoing peripheral arteriography
排除标准
- •Patients who respond favorably to phosphodiesterase-5 inhibitors
- •known non-vascular etiologies of their erectile dysfunction
- •probable neurogenic erectile dysfunction due to radiation injury, surgery, or transurethral resection of the prostate
- •calculated GFR < 60 ml/min/1.73 m2 will also be excluded
- •disease that necessitates complex percutaneous intervention will be excluded per the investigators discretion
结局指标
主要结局
Distal aortography with iliofemoral run-off will be performed to evaluate disease in the common and internal iliac arteries.
时间窗: During Procedural Cath
次要结局
- Intra-arterial nitroglycerin (or papaverine or tolazoline if nitroglycerin is contraindicated) will be used to facilitate angiographic visualization of the internal pudendal and penile arteries.(During Procedural Cath)
- Selective angiography of the internal pudendal artery (and accessory pudendal artery if present) will be performed bilaterally.(During Procedural Cath)