A Pan-Vascular Prospective Cohort-Based Study of the Effect of Lp (a) on Atherosclerosis in a Population with Diabetes Mellitus and Abnormal Blood Glucose

Not Applicable

Recruiting

• Conditions: diabetes

• Registration Number: ChiCTR2400088874
• Lead Sponsor: The Third Xiangya Hospital of Central South University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Age 40-70 years old (including the threshold), gender is not limited; <br>2. ASCVD risk groups: (1) have a family history of early onset cardiovascular disease (male <55 years old, female <65 years old); (2) have familial hypercholesterolemia; (3) smoking; (4) hypertension; (5) diabetes mellitus; (6) hyperlipidemia; (7) overweight or obesity (BMI =24Kg/m2); (8) cardiovascular risk assessment (China-) PAR score is high-risk (10-year ASCVD risk assessment >10% or lifetime risk >32.8%); (9) Chronic Kidney Disease (CKD); those who satisfy any two of the above conditions, or those who have atherosclerosis such as arterial plaques, atherosclerosis or stenosis of blood vessels, etc., can be directly entered into the primary screening cohort. <br>3. Those who are able to voluntarily accept the monthly/yearly physical examination and follow up after the enrollment; <br>4. Those who agree to be enrolled in the study in a timely manner. ) Agree to feedback information related to diabetes diagnosis during outpatient visits to the investigator in a timely manner during the course of the study;<br>5. Those who are fully aware of the study and voluntarily sign the informed consent form.

Exclusion Criteria

1. Persons with previous cardiovascular endpoint events: myocardial infarction, stroke, transient ischemic attack, coronary intervention or other revascularization procedures, unstable angina, and hospitalization due to acute heart failure events; <br>2. Persons who have undergone major surgical procedures such as transplantation and other surgical treatments; <br>3. Persons who suffer from autoimmune disorders, malignant neoplasms, hereditary disorders, and psychiatric disorders/disabilities that, in the judgment of the investigator, make it inadvisable to participation in this study; <br>4. those with poor compliance who, in the judgment of the investigator, are unable to complete the study.

Study & Design

• Study Type: Observational study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Lp(a);Cervical Vascular Ultrasound;

Secondary Outcome Measures

Name	Time	Method
height;weight;waist measurement;blood pressure;liver function;kidney function;fasting blood glucose;blood lipid;glycosylated haemoglobin;routine blood;homocysteine;Heart fatty acid protein;Myeloperoxidase;Electrocardiogram results;chest X-ray;Results of abdominal ultrasound;