Effect of various physiological stimuli on Blood Pressure and Cerebral Oxygenatio
Not Applicable
- Registration Number
- CTRI/2022/02/040149
- Lead Sponsor
- A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Normotensive (SBP < 130 mmHg and DBP <85 mmHg) ( according to International society of Hypertension, global hypertension practice guidelines, AHA, 2020)
Exclusion Criteria
Structural heart disease any other CVs disorder eg history of MI heart failure orthostatic intolerance or any cardiovascular medications
CNS disease eg Parkinson disease stroke or Alzheimer dementia
Head injury psychotropic drug abuse alcohol abuse or nicotine dependence.
Any chronic illness like Diabetes mellitus Chronic liver failure Chronic renal failure Thyrotoxicosis or Myxoedema
History of recurrent or unexplained syncope
Previous scalp wounds and pre-existing skin diseases of the forehead.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Heart rate and BP systolic, diastolic and MAP during standard 15 second epochs during each phase, pre and post stimuli. <br/ ><br>2.For first 10 minutes resting cardiovascular tone assessment <br/ ><br>HRV and BPV parameters: LF power HF power LF/HF ratio SDRR RMSSD and pRR50. <br/ ><br>Frequency resolved analysis of fNIRS parameters: LF power HF power LF/HF ratio <br/ ><br>3.Frequency resolved analysis of HR BP and fNIRS recordings for Paced breathing at 0.1 Hz, head up tilts at 30°and 60° and head down tilt at -6° <br/ ><br> <br/ ><br>Timepoint: Recording of a subject will be done on two different days within a week based on fixed paradigms and pre training of subjects.
- Secondary Outcome Measures
Name Time Method ATimepoint: NA