Cardiovascular Injury and Cardiac Fitness in Locally Advanced Non-Small Cell Lung Cancer Patients Receiving Model Based Personalized Chemoradiation
- Conditions
- Locally Advanced Lung Non-Small Cell CarcinomaStage III Lung Cancer AJCC v8Stage IIIA Lung Cancer AJCC v8Stage IIIB Lung Cancer AJCC v8Stage IIIC Lung Cancer AJCC v8
- Registration Number
- NCT05010109
- Lead Sponsor
- M.D. Anderson Cancer Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria:<br><br> - Patient with histologic diagnosis of non-small cell lung cancer<br><br> - The recommended treatment is thoracic radiation therapy combined with concurrent<br> systemic therapy (chemotherapy and/or immunotherapy) with or without neoadjuvant<br> and/or adjuvant systemic therapy (chemotherapy, immunotherapy, targeted therapy)<br><br> - >= 18 years of age<br><br> - Karnofsky performance status (KPS) >= 70<br><br> - Willing and able to sign informed consents<br><br> - Able and willing to perform 6minute walking test<br><br> - Able and willing to preform required cardiac imaging examinations<br><br>Exclusion Criteria:<br><br> - Unable or unwilling to give written informed consent<br><br> - Previous history of RT to the thorax<br><br> - Any contraindication for cardiac imaging<br><br> - Pregnant or breast-feeding<br><br> - Renal failure necessitating dialysis<br><br> - Unable to perform protocol tests<br><br> - Contraindication for any protocol tests
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Increase in level of hs-TnT >= 5ng/L;Incidence of grade >= 2 cardiovascular events
- Secondary Outcome Measures
Name Time Method Overall cardiac fitness;EuroQol 5 Dimension 5 Level: Patient reported outcomes;MD Anderson Symptom Inventory-Lung Cancer: Patient Report outcomes;Overall survival