Assessing cardiovascular diseases through the eye

Not Applicable

Recruiting

Conditions: cardiovascular diseases
Coronary artery disease
Hypertension
Cardiovascular - Coronary heart disease
Cardiovascular - Hypertension

Registration Number: ACTRN12622001234707

Lead Sponsor: Hadi Afsharan

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 400

Inclusion Criteria

Age 18 years or older
Willing to give consent.
No cataract or corneal opacity.
For the patients (first cohort): patients who have undergone or are expected to undergo coronary angiography.
• For the healthy subjects (second cohort): people who have not been diagnosed with coronary artery disease and are deemed to be healthy.

Exclusion Criteria

- Patients unable to provide written informed consent.
- Cognitive impairment
- Patients with very poor vision or who have too many cataracts, as these are likely to obstruct the imaging beam, leading to images with insufficient signal-to-noise for analysis.
- Patients who are not able to fixate.
- For some other reason retinal imaging is not feasible.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Birefringence of the retinal blood vessel assessed for CAD patients using PS-OCT[ Cumulative data will be assessed at the conclusion of the study which is expected to be two years after the first participant imaging];The thickness of the retinal blood vessel assessed for CAD patients using PS-OCT[ Cumulative data will be assessed at the conclusion of the study which is expected to be two years after the first participant imaging];Birefringence of the retinal blood vessel assessed for healthy people using PS-OCT[ Cumulative data will be assessed at the conclusion of the study which is expected to be two years after the first participant imaging]

Secondary Outcome Measures

Name	Time	Method
assessment of the integrity of the blood vessels for CAD patients and healthy participants using blood vessel wall birefringence index (BBI) determined by PS-OCT data.<br>[ Cumulative data will be assessed at the conclusion of the study which is expected to be two years after the first participant imaging];The thickness of the retinal blood vessel assessed for healthy people using PS-OCT (primary outcome)[ Cumulative data will be assessed at the conclusion of the study which is expected to be two years after the first participant imaging]