Phosphorus and Calcium Removal During Long Hemodialysis Treatment Sessions
- Conditions
- Kidney Failure
- Interventions
- Device: NxStage System One (NxStage Medical, Lawrence, MA)
- Registration Number
- NCT00633308
- Lead Sponsor
- Indiana University
- Brief Summary
The purpose of this sudy is to determined the effect of dialysate volume and treatment time on phosphate and calcium removal in stage V chronickidney disease patients treated by hemodialysis using the System One (NxStage Medical, Lawrence, MA)
- Detailed Description
Ten patients will be recruited from those routinely treated in-center or at home using the Systerm One at the clinical centers. Each patient will be studiesd on 4 separate occastions. Treatments under the following conditions will each be performed on each study patient, at least one week apart:
1. Treatment for 8 hrs uding 40L of dialysate
2. Treatment for 8 hrs using 60L of dialysate
3. Treatment for 5 hrs using 40L of dialysate
4. Treatment for 5 hrs using 60L of dialysate
Blood samples will be collected and assayed for the concentrations of urea, phosphate, calcium, bicarbonate, beta-2-microglobulin and albumin using standard assays.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- Stage V chronic kidney patients with minimal or no residual renal functin
- Medically unstable
- Hematocrit less than 28%
- Hepatitis B positive, hepatitis C positive or HIV positive
- Pregnant women
- Minors below 18 years of age
- Active psychiatric disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description A NxStage System One (NxStage Medical, Lawrence, MA) Long hemodialysis
- Primary Outcome Measures
Name Time Method the effect of dialysate volume and treatment time on phosphage and calcium removal 4 treatments
- Secondary Outcome Measures
Name Time Method