To build a precise diagnosis and treatment system for membranous nephropathy based on the correlation between intestinal microecology and TCM tongue diagnosis

Phase 1

• Conditions: CKD M

• Registration Number: ITMCTR2000004026
• Lead Sponsor: onghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Diagnosed as primary membranous nephropathy by renal biopsy and clinical examination;
2. Aged 18-75 years old;
3. CKD<=3 stage (GFR>30ml/min), 24-hour urine protein quantitative >=1g;

Exclusion Criteria

1. Rapidly progressive membranous nephropathy (progressive decline in renal function, necrotizing capillary vasculitis and >50% large crescent formation on renal biopsy);
2. Membranous nephropathy with IgA nephropathy;
3. Have received immunosuppressive drugs or cytotoxic drugs for more than 4 weeks in the past 6 months;
4. Have received glucocorticoids (prednisone or prednisone) at a dose of more than 20 mg/d for more than 4 weeks in the past 6 months;
5. Combined with life-threatening complications such as severe infection;
6. Those with positive HBV serological indicators other than HbsAb and those with abnormal transaminase in continuous liver function tests;
7. Patients with malignant tumors or patients with malignant tumor history, history of HIV infection, history of mental illness, acute central nervous system disease, severe gastrointestinal disease, and patients who are prohibited from using immunosuppressive agents;
8. Abnormal glucose metabolism, fasting blood sugar exceeding 6.2mmol/L;
9. Pregnant or lactating women;
10. Undergoing other clinical trial research;
11. Combined with serious diseases and dysfunction of other organs;
12. Taking probiotics for treatment in the past month;
13. The blood pressure of hypertension is controlled at 130/80mmHg.

Study & Design

• Study Type: Observational study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ALB;24hupro;Scr;