Oxidative Stress in Obstructive Sleep Apnea: Correlation of Biomarkers and Nasal CPAP Compliance
- Conditions
- Sleep Apnea, Obstructive
- Registration Number
- NCT01661699
- Lead Sponsor
- Georgetown University
- Brief Summary
The purpose of this study is to check blood and urine levels to further define markers/tests in the blood and urine that would be useful in following patients with obstructive sleep apnea and then to see if by wearing CPAP every night, these markers can be reduced. This research is being done because currently there are no effective blood or urine markers to determine how well CPAP is working.
- Detailed Description
The goal of this study is to further define biomarkers that would be useful in following patients with obstructive sleep apnea and examining their response to compliance to therapy with CPAP. To date no correlation between biomarkers of oxidative stress and compliance to CPAP has been measured. CPAP is the most effective treatment for obstructive sleep apnea and has been show to reduce blood pressure and decrease oxidative stress.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
- Men and Women over 18 years suspected of having sleep apnea
- Those under 18 years or not suspected of having sleep apnea
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Determining biomarkers for polysomnography characteristics before and after CPAP treatment 6 months The primary objective of this pilot study will determine the biomarkers for polysomnography characteristics with CPAP treatment from baseline to 6 months in patients with obstructive sleep apnea. The results will guide biomarker selection for full scale studies.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Georgetown University Hospital
🇺🇸Washington, District of Columbia, United States