Evaluation of Potential Biomarkers for Obstructive Sleep Apnea and the Effect of Positive Pressure Treatment

Completed

• Conditions: Obstructive Sleep Apnea

• Registration Number: NCT01976052
• Lead Sponsor: Karolinska University Hospital

Brief Summary

Potential biomarkers for obstructive sleep apnea (OSA), and full genomic screening will be evaluated and correlated to the degree of OSA and to effect of CPAP-treatment measured by polygraphy.

Detailed Description

This project includes two parts:

* Genomic screening

* Biomarkers

Study Timeline

• Study Start: 2013-10-01
• Study First Submitted: 2013-10-21
• Study First Submitted QC: 2013-10-28
• Study First Posted: 2013-11-05
• Primary Completion: 2017-06-01
• Study Completion: 2017-06-01
• Status Verified: 2020-10
• Last Update Submitted: 2020-10-13
• Last Update Posted: 2020-10-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

Not provided

Exclusion Criteria

• If they no not fulfil the inclusion criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Biomarker	Comparison between 0, 3 and 12 month	Biomarkers related to inflammation, hypoxia, oxidative stress, redox and the central nervous system will be measured

Secondary Outcome Measures

Name	Time	Method
Genomics	Comparison between 0, 3, 12 month	Genomic screening by microarray
Apnea hypopnea index	Comparision between 0, 3 and 12 month	Apnea hypopnea index at 0, 3 and 12 month after treatment with CPAP in the obstructive sleep apnea groups
Exhaled nitric oxide	Comparision at 0, 3 and 12 month	Measurement of exhaled nitric oxide

Trial Locations

Locations (1)

Department of Anesthesiology, Surgical Sciences and Intensive Care Medicine, Karolinska University Hospital, Solna; 🇸🇪 Stockholm, Sweden