Combined treatment with thyroxine plus triiodothyronine for primary hypothyroidism in humans

Completed

• Conditions: Hypothyroidism; Nutritional, Metabolic, Endocrine; Hypothroidism

• Registration Number: ISRCTN85948357
• Lead Sponsor: Hospital Ramón y Cajal, Madrid (Spain)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-07-28
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 0

Inclusion Criteria

Inclusion criteria required women between 18 and 70 years-old, presenting with overt primary hypothyroidism as defined by increased thyroid-stimulating hormone (TSH) and decreased free T4 serum levels at diagnosis, who maintained serum TSH levels within the normal range on a stable levothyroxine dose of 100 µg per day for at least the previous year.

Exclusion Criteria

Exclusion criteria included mental illnesses, affective disorders or use of psychotropic drugs, cardiovascular, renal or hepatic disease, osteoporosis, and treatment with drugs that may interfere with thyroid function other than levothyroxine.

The external euthyroid control group was composed of healthy women.

Study & Design

• Study Type: Interventional
• Study Design: Not specified