Measurement of Neonatal Microvascular Hemodynamics Using Non-invasive Optical Technologies
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Infant, Premature, Diseases
- Sponsor
- University of California, Irvine
- Enrollment
- 32
- Locations
- 1
- Primary Endpoint
- Normal Blood flow in premature infant
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Alterations to microvascular blood flow in premature infants, are known to contribute to several major disease entities.
The optically-measured tissue blood flow, to determine tissue perfusion that can be use to detect blood loss.
Detailed Description
The researchers want to use optical technologies to non-invasively detect blood flow that can tell the onset of blood loss. The research can measure blood flow in stable premature infants in the Neonatal Intensive Care Unit over the duration of several weeks. The technologies are Laser Speckle Imaging and Diffuse Optical Spectroscopy. Laser Speckle Imaging non-contact imaging technology, is sensitive to blood flow in superficial tissues. Diffuse Optical Spectroscopy, a probe-based contact technology like pulse oximetry, measures hemoglobin concentrations and states deeper below the skin surface.
Investigators
Beckman Laser Institute and Medical Center
Omid Fathi, M.D., Pediatrics
University of California, Irvine
Eligibility Criteria
Inclusion Criteria
- •premature infants born or transferred to neonatal intensive care unit with a gestational age of 28-35 weeks
Exclusion Criteria
- •NONE premature infants born or transferred to neonatal intensive care unit
Outcomes
Primary Outcomes
Normal Blood flow in premature infant
Time Frame: up to 4 weeks