Evaluation of Salivary Levels of miR-155 and IL-10 in Oral Lichen Planus Patients Before and After Treatment With Topical Corticosteroid
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Measurement of salivary levels of miR-155 in OLP before treatment
研究概览
简要总结
Thirty patients will be recruited from the outpatient clinic of the faculty of dentistry.fifteen systemically healthy individuals with normal mucosa and fifteen atrophic/erosive oral lichen planus patients. Oral lichen planus patients will be treated with a topical steroid and miR-155 and IL-10 will be assessed in saliva before and after 4 weeks of topical steroids use
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients clinically and histopathologically diagnosed as having atrophic/erosive OLP.
- •Patients free from any other oral lesions
- •cooperative patients who agrees to take the supplied medications.
- •Patients who are systemically healthy
排除标准
- •Patients suffering from any systemic disease.
- •Treatment with any systemic treatment such as systemic steroids, other immunosuppressive drugs or non-steroidal anti-inflammatory drugs at least eight weeks.
- •Treatment with any oral topical medications for at least four weeks prior to the study.
- •Pregnant and lactating women.
研究组 & 干预措施
OLP patients
fifteen patients with atrophic /erosive OLP will receive treatment with topical triamcinolone acetonide in orabase 1mg/g 3 times /day and assessed every week for 4 weeks
干预措施: Triamcinolone Acetonide in orabase (Drug)
结局指标
主要结局
Measurement of salivary levels of miR-155 in OLP before treatment
时间窗: baseline
assessment of miR-155 in saliva of patients with OLP before treatment
Measurement of salivary levels of IL-10 in OLP before treatment
时间窗: baseline
assessment of IL-10 in saliva of patients with OLP before treatment
次要结局
- Measurement of salivary levels of miR-155 in OLP after treatment(4 weeks)
- Measurement of salivary levels of IL-10 in OLP after treatment(4 weeks)
研究者
Eman Mohamed Amr
Associate Professor
Cairo University