Does starting children on an insulin pump improve how blood vessels work due to less variable blood glucose levels?

Not Applicable

• Conditions: type I diabetes; cardiovascular disease; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12608000189325
• Lead Sponsor: Adelaide Children, Youth abd Women's Health Service

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-04-11
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Children with type I diabetes from the diabetes clinic at the Adelaide Chidren, Youth and Women's Health Service on the waiting list to commence an insulin pump

Exclusion Criteria

smoking, history of allergic reaction to nitrates or nitrites, pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glucose variability. Glucose variability will be assessed by using a Medtronic Minimed Paradigm Real-Time continuous glucose monitoring system (CGMS).[just prior and then 3 weeks after commencing an insulin pump];Vascular function. Vascular endothelial function will be assessed using flow-mediated dilatation (FMD).[Just prior and then 3 weeks after commencing an insulin pump]

Secondary Outcome Measures

Name	Time	Method
vascular risk factors - venous blood test for : HbA1c, fasting lipids and glucose, hsCRP, adiponectin[just prior and then 3 weeks after commencing an insulin pump]