Pressure limit selection during neonatal assist control volume guarantee ventilation: A randomised crossover trial

Not Applicable

Completed

• Conditions: eonatal ventilation; Neonatal ventilation; Respiratory - Other respiratory disorders / diseases; Reproductive Health and Childbirth - Complications of newborn

• Registration Number: ACTRN12610000886088
• Lead Sponsor: Royal Women's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-10-19
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

Stable ventilated infants, ventilated using assist control volume guarantee (AC/VG) for previous 24 hours.

Exclusion Criteria

Ventilator changes in previous 4 hours, pH < 7.2, pCO2>80 mmHg, FiO2 > 0.8, acute pneumothoax/pulmonary interstitial emphysema, significant congenital abnormality, severe PVH, receiving muscle relaxants or morphine infusion > 20 ug/kg/hr

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Proportion of ventilator inflations with expired tidal volume with 90-110% of target tidal volume, identified from the ventilator waveforms/trigger data[These data are measured continually. The outcome is defined as the number of inflations in range / total number of inflations over the epoch]

Secondary Outcome Measures

Name	Time	Method
Ventilator parameters determined from the ventilator data including:<br>Rate, mean airway pressure, peak inflating pressure[The data are measure continually over the epoch. Epoch averages will be compared];Measures of cardiorespiratory stability including:<br>FiO2, SpO2, TcCO2, HR and BP assessed using the ventilator data, Masimo Radical pulse oximeter, and Philips Intellivue series monitor with transcutaneous module[These data are recorded every minute. The change over the epoch will be measured (average data from last 2 mins of epoch minus average data from last 2 mins of run in period prior to epoch)]