The Vitamin C after Cardiac Surgery Study

Phase 2

Completed

• Conditions: ow blood pressure; Vasoplegia; Low blood pressure; Cardiovascular - Other cardiovascular diseases; Surgery - Other surgery

• Registration Number: ACTRN12617000793314
• Lead Sponsor: Austin Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-05-30
• Last Update Posted: 14 January 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Patients aged greater than or equal to 18 years
Admitted to the ICU for less than 6 hours following cardiac surgery
Vasoplegic syndrome in the postoperative period defined as:
a) need for continuous vasopressor infusion to maintain a mean arterial pressure greater than 65 mmHg AND
b) cardiac index equal to or greater than 2.2 L/min/m2 OR central venous O2 saturation less than 60%

Exclusion Criteria

Pregnancy
Use of vasopressors or inotropes in the preoperative period
Off-pump cardiac surgery
Chronic use of corticosteroid therapy
History of oxalate nephrolithiasis
Haemochromatosis
Glucose 6 phosphate dehydrogenase deficiency
Treating physician believes there is a cause for shock other than vasoplegic syndrome (eg: bleeding, fluid requirement, pneumothorax, pacemaker issues, or heart failure)
Treating clinician believes the study is not in the patient’s best interests

Study & Design

• Study Type: Interventional
• Study Design: Not specified