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临床试验/NCT03797352
NCT03797352Unknown不适用

HOPE (Healthy Older People Everyday) To Age in Place: Design and Implementation of an Innovative and Cost Effective Electronic Rapid Geriatric Assessment Tool for the Screening and Management of Frailty in Community Dwelling Older Adults

National University Hospital, Singapore0 个研究点目标入组 1,000 人开始时间: 2019年1月最近更新:
适应症
干预措施

试验速览

阶段
不适用
入组人数
1,000
主要终点
Changes in frailty status

研究概览

简要总结

Certain clinical syndromes eg frailty, sarcopenia, dementia, depression, cognitive impairment, vision impairment, falls in older adults carry an increased risk for poor health outcomes and if identified early, can be prevented, delayed or reversible. There is evidence to suggest that exercise and dietary intervention can help delay or prevent sarcopenia, frailty and dementia. Through early screening and detection of frailty and cognitive impairment, the investigators will be able to identify participants at risk of future physical or mental decline in primary care setting and ambulatory care clinics. Those prefrail, frail but ambulant with / without cognitive impairment will be randomised to dual task exercise with/without cognitive stimulation therapy and health education. The main hypothesis is that the combination of multicomponent group exercise activities and dual task exercise is effective in reversing frailty and improving cognition.

详细描述

Major challenges in the Singapore healthcare landscape include a rapidly aging population, due to rising life expectancy at birth combined with declining total fertility, and an epidemiological transition in the main source of disease burden from communicable and infectious conditions to non-communicable, chronic conditions. While acute care will always remain a crucial component of healthcare delivery systems, the increased healthcare burden centered on chronic diseases and the concomitant aging population is putting increased strain on healthcare resources. Frailty is reversible and progression to dementia can be delayed. From most recent study, prevalence of pre-frailty is 37% and mild cognitive impairment about 15-20%. WHO's definition of healthy ageing is maintaining functional ability. Cognicise, a dual task exercise has shown to delay decline in cognition and there are many studies which shows aerobic exercise improves endurance. Patients seen in Geriatric, Medicine Clinic or polyclinics who are prefrail, frail but ambulant with / without cognitive impairment will be randomised to dual task exercise with/without cognitive stimulation therapy and health education. In addition, high protein diet has been shown to improve muscle protein synthesis. Therefore, the aims of the study are to assess: a) Assess the effectiveness of dual task exercise with/without cognitive stimulation therapy b) Effect of health education alone for delaying the progression to dementia and mobility decline c) Assess impact of exercise on inflammatory and bone health biomarkers eg IL, TNF, Osteocalcin, sclerostin and C telopeptide in a subgroup of older adults randomly selected.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Factorial
主要目的
Treatment
盲法
Single (Investigator)

入排标准

年龄范围
65 Years 至 120 Years(Older Adult)
性别
All
接受健康志愿者

入选标准

  • Pre frail or frail but ambulant (Frail scale score of at least 1)
  • Able to walk 400m aided or unaided (at least one bus stop away)
  • Has no significant heart or lung problems
  • Grip strength not more than 25kg for males and 18kg for females

排除标准

  • Unable to give consent personally
  • Wheelchair bound or at a very high falls risk
  • Unable to participate due to underlying health problems including severe weakness due to stroke
  • Undergoing active cancer treatment

研究组 & 干预措施

Control

No Intervention

Receive healthy ageing advice every 3 months for the duration of 12 months

Intervention

Experimental

To participate in supervised Multicomponent exercise (combined exercise and cognitive activity) up to three times a week for 6 months and receive healthy ageing advice

干预措施: Multicomponent exercise (Other)

结局指标

主要结局

Changes in frailty status

时间窗: 1 year

Changes in frailty status by 5-item FRAIL scale Scale range from 0 to 5, the higher the value, the more frail (3 or greater = frailty; 1 or 2 = prefrail)

Functional improvement

时间窗: 1 year

Changes in short physical performance battery (SPPB) summary score 3 subscales (range from 0 to 4 for balance, gait speed and chair stand) summed to give total score range from 0 to 12. The higher the value, the better the performance of lower extremity.

次要结局

  • Upper extremity strength(1 year)
  • Reduction of prevalence of depression(1 year)
  • reduction in social isolation(1 year)
  • Improved quality of life(1 year)
  • Improved cognition(1 year)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Medicine

Head & Senior Consultant, Division of Geriatric Medicine

National University Hospital, Singapore

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