Efficacy of glyceryl trinitrate to facilitate the rewarming process during cardiopulmonary bypass

Not Applicable

Completed

• Conditions: Surgery; Cardiac surgery necessitating CPB

• Registration Number: ISRCTN10480871
• Lead Sponsor: Mater Misercordiae University Hospital

Brief Summary

2020 results in https://doi.org/10.1186/s13019-020-01258-0 (added 13/08/2020)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-08-16
• Study Completion: 2019-08-14
• Last Update Posted: 24 August 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 82

Inclusion Criteria

1. Adult patients (aged over 18)
2. Capacity to consent
3. Undergoing cardiac surgery necessitating CPB

Exclusion Criteria

1. Age < 18 years old
2. Allergy to GTN
3. Cardiac surgery necessitation deep hypothermic circulatory arrest (DHCA)
4. Cardiac surgery not involving CPB (eg. off-pump cardiopulmonary bypass grafting)
5. Lack of capacity to consent
6. Use of TIVA propofol whilst on CPB

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Time to completion of rewarming prior to separation from CPB circuit<br> 2. Early post-op patient peripheral – core temperature gradient<br> 3. Time to maintenance of normothermia (core temperature > 36.5°C) for minimum of 2 hours in the initial post-op period and including skin temperature reaching a plateau<br> 4. Plasma lactate concentrations initially post-CPB<br><br> Nasopharyngeal, skin and bladder temperature are recorded at baseline post induction of anaesthesia, rewarming from CPB, separation from CPB, application of surgical dressing (end of surgery) and arrival in ICU.<br>

Secondary Outcome Measures

Name	Time	Method
Time to extubation, measured from application of surgical dressing (end of surgery) to actual time of removal of endotracheal tube (extubation)